This page lists the head-to-head record of Santa Clara vs Vitoria Guimaraes including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Vitoria Guimaraes | Santa Clara | Draws |
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| Total Matches | 22 | 13 | 7 | 2 |
| At D. Afonso Henriques | 10 | 3 | 6 | 1 |
| At Estadio de Sao Miguel | 12 | 10 | 1 | 1 |
| Division2 Matches | 2 | 2 | 0 | 0 |
| Cup Matches | 1 | 0 | 1 | 0 |
| Portuguese Liga Matches | 19 | 11 | 6 | 2 |
| Total Goals Scored | 49 | 32 | 17 | |
Last 50 Vitoria Guimaraes vs Santa Clara Matches
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| 2025 4 October | | Portuguese Liga | Guimaraes | 2 - 1 | Santa Clara |
| 2025 5 April | | Portuguese Liga | Guimaraes | 2 - 0 | Santa Clara |
| 2024 10 November | | Portuguese Liga | Santa Clara | 1 - 0 | Guimaraes |
| 2023 5 March | | Portuguese Liga | Santa Clara | 1 - 3 | Guimaraes |
| 2022 9 September | | Portuguese Liga | Guimaraes | 1 - 0 | Santa Clara |
| 2022 1 May | | Portuguese Liga | Guimaraes | 1 - 1 | Santa Clara |
| 2021 17 December | | Portuguese Liga | Santa Clara | 1 - 0 | Guimaraes |
| 2021 17 April | | Portuguese Liga | Guimaraes | 1 - 0 | Santa Clara |
| 2020 21 December | | Portuguese Liga | Santa Clara | 0 - 4 | Guimaraes |
| 2020 13 December | | Cup | Guimaraes | 0 - 1 | Santa Clara |
| 2020 24 July | | Portuguese Liga | Santa Clara | 2 - 2 | Guimaraes |
| 2020 18 January | | Portuguese Liga | Guimaraes | 1 - 0 | Santa Clara |
| 2019 30 March | | Portuguese Liga | Santa Clara | 1 - 0 | Guimaraes |
| 2018 11 November | | Portuguese Liga | Guimaraes | 2 - 0 | Santa Clara |
| 2007 17 March | | Division2 | Santa Clara | 0 - 1 | Guimaraes |
| 2006 21 October | | Division2 | Guimaraes | 1 - 0 | Santa Clara |
| 2003 22 February | | Portuguese Liga | Santa Clara | 2 - 1 | Guimaraes |
| 2002 5 October | | Portuguese Liga | Guimaraes | 5 - 0 | Santa Clara |
| 2002 7 February | | Portuguese Liga | Guimaraes | 1 - 0 | Santa Clara |
| 2001 15 September | | Portuguese Liga | Santa Clara | 2 - 0 | Guimaraes |
| 2000 13 May | | Portuguese Liga | Santa Clara | 3 - 2 | Guimaraes |
| 2000 15 January | | Portuguese Liga | Guimaraes | 2 - 1 | Santa Clara |
Biggest Vitoria Guimaraes Victory vs Santa Clara
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| 2002 5 October | | Portuguese Liga | Guimaraes | 5 - 0 | Santa Clara |
Biggest Santa Clara Victory vs Vitoria Guimaraes
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| 2001 15 September | | Portuguese Liga | Santa Clara | 2 - 0 | Guimaraes |
Biggest Vitoria Guimaraes Defeat vs Santa Clara
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| 2001 15 September | | Portuguese Liga | Santa Clara | 2 - 0 | Guimaraes |
Biggest Santa Clara Defeat vs Vitoria Guimaraes
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| 2002 5 October | | Portuguese Liga | Guimaraes | 5 - 0 | Santa Clara |
Last 5 Vitoria Guimaraes Home Matches
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| 2025 1 November | | Portuguese Liga | Guimaraes | 0 - 3 | Benfica |
| 2025 4 October | | Portuguese Liga | Guimaraes | 2 - 1 | Santa Clara |
| 2025 20 September | | Portuguese Liga | Guimaraes | 1 - 1 | Sporting Braga |
| 2025 30 August | | Portuguese Liga | Guimaraes | 1 - 1 | Arouca |
| 2025 16 August | | Portuguese Liga | Guimaraes | 3 - 2 | Estoril |
Last 5 Santa Clara Home Matches
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| 2025 8 November | | Portuguese Liga | Santa Clara | 1 - 2 | Sporting Lisbon |
| 2025 25 October | | Portuguese Liga | Santa Clara | 2 - 0 | AVS |
| 2025 27 September | | Portuguese Liga | Santa Clara | 1 - 2 | Tondela |
| 2025 20 September | | Portuguese Liga | Santa Clara | 2 - 1 | Alverca |
| 2025 31 August | | Portuguese Liga | Santa Clara | 0 - 0 | Estrela P |
Last 5 Vitoria Guimaraes Away Matches
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| 2025 8 November | | Portuguese Liga | Tondela | 0 - 1 | Guimaraes |
| 2025 26 October | | Portuguese Liga | Famalicao | 2 - 0 | Guimaraes |
| 2025 19 October | | Cup | Uniao Lamas | 0 - 1 | Guimaraes |
| 2025 28 September | | Portuguese Liga | Alverca | 2 - 0 | Guimaraes |
| 2025 14 September | | Portuguese Liga | Estrela P | 0 - 2 | Guimaraes |
Last 5 Santa Clara Away Matches
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| 2025 3 November | | Portuguese Liga | Gil Vicente | 1 - 0 | Santa Clara |
| 2025 18 October | | Cup | Espinho | 0 - 0 | Santa Clara |
| 2025 4 October | | Portuguese Liga | Guimaraes | 2 - 1 | Santa Clara |
| 2025 12 September | | Portuguese Liga | Benfica | 1 - 1 | Santa Clara |
| 2025 6 September | | Portuguese Liga | Estoril | 0 - 1 | Santa Clara |