This page lists the head-to-head record of Man Utd vs Southampton including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Southampton | Man Utd | Draws |
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| Total Matches | 98 | 17 | 55 | 26 |
| At St Mary's Stadium | 48 | 5 | 31 | 12 |
| At Old Trafford | 50 | 12 | 24 | 14 |
| FA Cup Matches | 3 | 0 | 3 | 0 |
| Carling Cup Matches | 1 | 0 | 1 | 0 |
| Premier League Matches | 94 | 17 | 51 | 26 |
| Total Goals Scored | 291 | 106 | 185 | |
Last 50 Southampton vs Man Utd Matches
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| 2025 16 January | | Premier League | Manchester United | 3 - 1 | Southampton |
| 2024 14 September | | Premier League | Southampton | 0 - 3 | Manchester United |
| 2023 12 March | | Premier League | Manchester United | 0 - 0 | Southampton |
| 2022 27 August | | Premier League | Southampton | 0 - 1 | Manchester United |
| 2022 12 February | | Premier League | Manchester United | 1 - 1 | Southampton |
| 2021 22 August | | Premier League | Southampton | 1 - 1 | Manchester United |
| 2021 2 February | | Premier League | Manchester United | 9 - 0 | Southampton |
| 2020 29 November | | Premier League | Southampton | 2 - 3 | Manchester United |
| 2020 13 July | | Premier League | Manchester United | 2 - 2 | Southampton |
| 2019 31 August | | Premier League | Southampton | 1 - 1 | Manchester United |
| 2019 2 March | | Premier League | Manchester United | 3 - 2 | Southampton |
| 2018 1 December | | Premier League | Southampton | 2 - 2 | Manchester United |
| 2017 30 December | | Premier League | Manchester United | 0 - 0 | Southampton |
| 2017 23 September | | Premier League | Southampton | 0 - 1 | Manchester United |
| 2017 17 May | | Premier League | Southampton | 0 - 0 | Manchester United |
| 2017 26 February | | Carling Cup | Manchester United | 3 - 2 | Southampton |
| 2016 19 August | | Premier League | Manchester United | 2 - 0 | Southampton |
| 2016 23 January | | Premier League | Manchester United | 0 - 1 | Southampton |
| 2015 20 September | | Premier League | Southampton | 2 - 3 | Manchester United |
| 2015 11 January | | Premier League | Manchester United | 0 - 1 | Southampton |
| 2014 8 December | | Premier League | Southampton | 1 - 2 | Manchester United |
| 2014 11 May | | Premier League | Southampton | 1 - 1 | Manchester United |
| 2013 19 October | | Premier League | Manchester United | 1 - 1 | Southampton |
| 2013 30 January | | Premier League | Manchester United | 2 - 1 | Southampton |
| 2012 2 September | | Premier League | Southampton | 2 - 3 | Manchester United |
| 2011 29 January | | FA Cup | Southampton | 1 - 2 | Manchester United |
| 2009 4 January | | FA Cup | Southampton | 0 - 3 | Manchester United |
| 2005 14 May | | Premier League | Southampton | 1 - 2 | Manchester United |
| 2005 11 March | | FA Cup | Southampton | 0 - 4 | Manchester United |
| 2004 3 December | | Premier League | Manchester United | 3 - 0 | Southampton |
| 2004 30 January | | Premier League | Manchester United | 3 - 2 | Southampton |
| 2003 30 August | | Premier League | Southampton | 1 - 0 | Manchester United |
| 2003 31 January | | Premier League | Southampton | 0 - 2 | Manchester United |
| 2002 1 November | | Premier League | Manchester United | 2 - 1 | Southampton |
| 2002 12 January | | Premier League | Southampton | 1 - 3 | Manchester United |
| 2001 21 December | | Premier League | Manchester United | 6 - 1 | Southampton |
| 2001 12 May | | Premier League | Southampton | 2 - 1 | Manchester United |
| 2000 27 October | | Premier League | Manchester United | 5 - 0 | Southampton |
| 2000 21 April | | Premier League | Southampton | 1 - 3 | Manchester United |
| 1999 24 September | | Premier League | Manchester United | 3 - 3 | Southampton |
| 1999 26 February | | Premier League | Manchester United | 2 - 1 | Southampton |
| 1998 2 October | | Premier League | Southampton | 0 - 3 | Manchester United |
| 1998 18 January | | Premier League | Southampton | 1 - 0 | Manchester United |
| 1997 12 August | | Premier League | Manchester United | 1 - 0 | Southampton |
| 1997 31 January | | Premier League | Manchester United | 2 - 1 | Southampton |
| 1996 25 October | | Premier League | Southampton | 6 - 3 | Manchester United |
| 1996 12 April | | Premier League | Southampton | 3 - 1 | Manchester United |
| 1995 17 November | | Premier League | Manchester United | 4 - 1 | Southampton |
| 1995 9 May | | Premier League | Manchester United | 2 - 1 | Southampton |
| 1994 30 December | | Premier League | Southampton | 2 - 2 | Manchester United |
Biggest Southampton Victory vs Man Utd
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| 1996 25 October | | Premier League | Southampton | 6 - 3 | Manchester United |
Biggest Man Utd Victory vs Southampton
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| 2021 2 February | | Premier League | Manchester United | 9 - 0 | Southampton |
Biggest Southampton Defeat vs Man Utd
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| 2021 2 February | | Premier League | Manchester United | 9 - 0 | Southampton |
Biggest Man Utd Defeat vs Southampton
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| 1996 25 October | | Premier League | Southampton | 6 - 3 | Manchester United |
Last 5 Southampton Home Matches
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| 2026 1 January | | Championship | Southampton | 0 - 0 | Millwall |
| 2025 20 December | | Championship | Southampton | 1 - 1 | Coventry City |
| 2025 9 December | | Championship | Southampton | 3 - 2 | West Bromwich Albion |
| 2025 6 December | | Championship | Southampton | 3 - 1 | Birmingham City |
| 2025 25 November | | Championship | Southampton | 3 - 0 | Leicester City |
Last 5 Man Utd Home Matches
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| 2026 17 January | | Premier League | Manchester United | 2 - 0 | Manchester City |
| 2026 11 January | | FA Cup | Manchester United | 1 - 2 | Brighton & Hove Albion |
| 2025 30 December | | Premier League | Manchester United | 1 - 1 | Wolverhampton Wanderers |
| 2025 26 December | | Premier League | Manchester United | 1 - 0 | Newcastle United |
| 2025 15 December | | Premier League | Manchester United | 4 - 4 | AFC Bournemouth |
Last 5 Southampton Away Matches
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| 2026 10 January | | FA Cup | Doncaster Rovers | 2 - 3 | Southampton |
| 2026 4 January | | Championship | Middlesbrough | 4 - 0 | Southampton |
| 2025 29 December | | Championship | Birmingham City | 1 - 1 | Southampton |
| 2025 26 December | | Championship | Oxford United | 2 - 1 | Southampton |
| 2025 13 December | | Championship | Norwich City | 2 - 1 | Southampton |
Last 5 Man Utd Away Matches
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| 2026 7 January | | Premier League | Burnley | 2 - 2 | Manchester United |
| 2026 4 January | | Premier League | Leeds United | 1 - 1 | Manchester United |
| 2025 21 December | | Premier League | Aston Villa | 2 - 1 | Manchester United |
| 2025 8 December | | Premier League | Wolverhampton Wanderers | 1 - 4 | Manchester United |
| 2025 30 November | | Premier League | Crystal Palace | 1 - 2 | Manchester United |