This page lists the head-to-head record of Man Utd vs Southampton including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Southampton | Man Utd | Draws |
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| Total Matches | 97 | 17 | 54 | 26 |
| At St Mary's Stadium | 47 | 5 | 30 | 12 |
| At Old Trafford | 50 | 12 | 24 | 14 |
| FA Cup Matches | 3 | 0 | 3 | 0 |
| Carling Cup Matches | 1 | 0 | 1 | 0 |
| Premier League Matches | 93 | 17 | 50 | 26 |
| Total Goals Scored | 287 | 105 | 182 | |
Last 50 Southampton vs Man Utd Matches
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| 2024 14 September | | Premier League | Southampton | 0 - 3 | Manchester United |
| 2023 12 March | | Premier League | Manchester United | 0 - 0 | Southampton |
| 2022 27 August | | Premier League | Southampton | 0 - 1 | Manchester United |
| 2022 12 February | | Premier League | Manchester United | 1 - 1 | Southampton |
| 2021 22 August | | Premier League | Southampton | 1 - 1 | Manchester United |
| 2021 2 February | | Premier League | Manchester United | 9 - 0 | Southampton |
| 2020 29 November | | Premier League | Southampton | 2 - 3 | Manchester United |
| 2020 13 July | | Premier League | Manchester United | 2 - 2 | Southampton |
| 2019 31 August | | Premier League | Southampton | 1 - 1 | Manchester United |
| 2019 2 March | | Premier League | Manchester United | 3 - 2 | Southampton |
| 2018 1 December | | Premier League | Southampton | 2 - 2 | Manchester United |
| 2017 30 December | | Premier League | Manchester United | 0 - 0 | Southampton |
| 2017 23 September | | Premier League | Southampton | 0 - 1 | Manchester United |
| 2017 17 May | | Premier League | Southampton | 0 - 0 | Manchester United |
| 2017 26 February | | Carling Cup | Manchester United | 3 - 2 | Southampton |
| 2016 19 August | | Premier League | Manchester United | 2 - 0 | Southampton |
| 2016 23 January | | Premier League | Manchester United | 0 - 1 | Southampton |
| 2015 20 September | | Premier League | Southampton | 2 - 3 | Manchester United |
| 2015 11 January | | Premier League | Manchester United | 0 - 1 | Southampton |
| 2014 8 December | | Premier League | Southampton | 1 - 2 | Manchester United |
| 2014 11 May | | Premier League | Southampton | 1 - 1 | Manchester United |
| 2013 19 October | | Premier League | Manchester United | 1 - 1 | Southampton |
| 2013 30 January | | Premier League | Manchester United | 2 - 1 | Southampton |
| 2012 2 September | | Premier League | Southampton | 2 - 3 | Manchester United |
| 2011 29 January | | FA Cup | Southampton | 1 - 2 | Manchester United |
| 2009 4 January | | FA Cup | Southampton | 0 - 3 | Manchester United |
| 2005 14 May | | Premier League | Southampton | 1 - 2 | Manchester United |
| 2005 11 March | | FA Cup | Southampton | 0 - 4 | Manchester United |
| 2004 3 December | | Premier League | Manchester United | 3 - 0 | Southampton |
| 2004 30 January | | Premier League | Manchester United | 3 - 2 | Southampton |
| 2003 30 August | | Premier League | Southampton | 1 - 0 | Manchester United |
| 2003 31 January | | Premier League | Southampton | 0 - 2 | Manchester United |
| 2002 1 November | | Premier League | Manchester United | 2 - 1 | Southampton |
| 2002 12 January | | Premier League | Southampton | 1 - 3 | Manchester United |
| 2001 21 December | | Premier League | Manchester United | 6 - 1 | Southampton |
| 2001 12 May | | Premier League | Southampton | 2 - 1 | Manchester United |
| 2000 27 October | | Premier League | Manchester United | 5 - 0 | Southampton |
| 2000 21 April | | Premier League | Southampton | 1 - 3 | Manchester United |
| 1999 24 September | | Premier League | Manchester United | 3 - 3 | Southampton |
| 1999 26 February | | Premier League | Manchester United | 2 - 1 | Southampton |
| 1998 2 October | | Premier League | Southampton | 0 - 3 | Manchester United |
| 1998 18 January | | Premier League | Southampton | 1 - 0 | Manchester United |
| 1997 12 August | | Premier League | Manchester United | 1 - 0 | Southampton |
| 1997 31 January | | Premier League | Manchester United | 2 - 1 | Southampton |
| 1996 25 October | | Premier League | Southampton | 6 - 3 | Manchester United |
| 1996 12 April | | Premier League | Southampton | 3 - 1 | Manchester United |
| 1995 17 November | | Premier League | Manchester United | 4 - 1 | Southampton |
| 1995 9 May | | Premier League | Manchester United | 2 - 1 | Southampton |
| 1994 30 December | | Premier League | Southampton | 2 - 2 | Manchester United |
| 1994 3 May | | Premier League | Manchester United | 2 - 0 | Southampton |
Biggest Southampton Victory vs Man Utd
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| 1996 25 October | | Premier League | Southampton | 6 - 3 | Manchester United |
Biggest Man Utd Victory vs Southampton
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| 2021 2 February | | Premier League | Manchester United | 9 - 0 | Southampton |
Biggest Southampton Defeat vs Man Utd
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| 2021 2 February | | Premier League | Manchester United | 9 - 0 | Southampton |
Biggest Man Utd Defeat vs Southampton
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| 1996 25 October | | Premier League | Southampton | 6 - 3 | Manchester United |
Last 5 Southampton Home Matches
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| 2024 18 December | | Carling Cup | Southampton | 1 - 2 | Liverpool |
| 2024 15 December | | Premier League | Southampton | 0 - 5 | Tottenham Hotspur |
| 2024 4 December | | Premier League | Southampton | 1 - 5 | Chelsea |
| 2024 24 November | | Premier League | Southampton | 2 - 3 | Liverpool |
| 2024 2 November | | Premier League | Southampton | 1 - 0 | Everton |
Last 5 Man Utd Home Matches
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| 2024 7 December | | Premier League | Manchester United | 2 - 3 | Nottingham Forest |
| 2024 1 December | | Premier League | Manchester United | 4 - 0 | Everton |
| 2024 28 November | | UEFA Europa League | Manchester United | 3 - 2 | Bodo / Glimt |
| 2024 10 November | | Premier League | Manchester United | 3 - 0 | Leicester City |
| 2024 7 November | | UEFA Europa League | Manchester United | 2 - 0 | PAOK |
Last 5 Southampton Away Matches
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| 2024 7 December | | Premier League | Aston Villa | 1 - 0 | Southampton |
| 2024 29 November | | Premier League | Brighton & Hove Albion | 1 - 1 | Southampton |
| 2024 9 November | | Premier League | Wolverhampton Wanderers | 2 - 0 | Southampton |
| 2024 26 October | | Premier League | Manchester City | 1 - 0 | Southampton |
| 2024 5 October | | Premier League | Arsenal | 3 - 1 | Southampton |
Last 5 Man Utd Away Matches
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| 2024 19 December | | Carling Cup | Tottenham Hotspur | 4 - 3 | Manchester United |
| 2024 15 December | | Premier League | Manchester City | 1 - 2 | Manchester United |
| 2024 12 December | | UEFA Europa League | Viktoria Plzen | 1 - 2 | Manchester United |
| 2024 4 December | | Premier League | Arsenal | 2 - 0 | Manchester United |
| 2024 24 November | | Premier League | Ipswich Town | 1 - 1 | Manchester United |