This page lists the head-to-head record of Perugia vs Siena including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Siena | Perugia | Draws |
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| Total Matches | 2 | 1 | 0 | 1 |
| At Montepaschi Arena | 1 | 0 | 0 | 1 |
| At | 1 | 1 | 0 | 0 |
| Serie A Matches | 2 | 1 | 0 | 1 |
| Total Goals Scored | 7 | 4 | 3 | |
Last 50 Siena vs Perugia Matches
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| 2004 23 January | | Serie A | Robur Siena | 2 - 1 | Perugia |
| 2003 30 August | | Serie A | Perugia | 2 - 2 | Robur Siena |
Biggest Siena Victory vs Perugia
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| 2004 23 January | | Serie A | Robur Siena | 2 - 1 | Perugia |
Biggest Perugia Defeat vs Siena
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| 2004 23 January | | Serie A | Robur Siena | 2 - 1 | Perugia |
Last 5 Siena Home Matches
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| 2023 23 April | | Serie C1 - A | Robur Siena | 1 - 2 | Virtus Entella |
| 2023 6 April | | Serie C1 - A | Robur Siena | 2 - 2 | Gubbio |
| 2023 18 March | | Serie C1 - A | Robur Siena | 0 - 0 | Alessandria |
| 2023 11 March | | Serie C1 - A | Robur Siena | 4 - 0 | Vis Pesaro |
| 2023 25 February | | Serie C1 - A | Robur Siena | 1 - 1 | Recanatese |
Last 5 Perugia Home Matches
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| 2025 10 January | | Serie C1 - A | Perugia | 1 - 0 | Athletic Carpi |
| 2024 22 December | | Serie C1 - A | Perugia | 1 - 1 | Pianese |
| 2024 9 December | | Serie C1 - A | Perugia | 2 - 1 | Citta di Campobasso |
| 2024 22 November | | Serie C1 - A | Perugia | 2 - 0 | Arezzo |
| 2024 10 November | | Serie C1 - A | Perugia | 0 - 0 | Ternana |
Last 5 Siena Away Matches
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| 2023 15 April | | Serie C1 - A | Fiorenzuola | 1 - 1 | Robur Siena |
| 2023 1 April | | Serie C1 - A | Fermana | 3 - 1 | Robur Siena |
| 2023 26 March | | Serie C1 - A | Carrarese | 3 - 0 | Robur Siena |
| 2023 14 March | | Serie C1 - A | Lucchese | 1 - 1 | Robur Siena |
| 2023 5 March | | Serie C1 - A | San Donato Tavarnelle | 1 - 1 | Robur Siena |
Last 5 Perugia Away Matches
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| 2025 5 January | | Serie C1 - A | Real SPAL | 1 - 1 | Perugia |
| 2024 15 December | | Serie C1 - A | Pontedera | 2 - 1 | Perugia |
| 2024 1 December | | Serie C1 - A | Sestri Levante | 2 - 2 | Perugia |
| 2024 16 November | | Serie C1 - A | Pineto | 3 - 1 | Perugia |
| 2024 3 November | | Serie C1 - A | Legnago Salus | 2 - 2 | Perugia |