This page lists the head-to-head record of Palermo vs Siena including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Siena | Palermo | Draws |
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| Total Matches | 23 | 7 | 9 | 7 |
| At Montepaschi Arena | 12 | 4 | 6 | 2 |
| At Stadio Renzo Barbera | 11 | 3 | 3 | 5 |
| Cup Matches | 1 | 0 | 0 | 1 |
| Serie B Matches | 6 | 2 | 2 | 2 |
| Serie A Matches | 16 | 5 | 7 | 4 |
| Total Goals Scored | 60 | 30 | 30 | |
Last 50 Siena vs Palermo Matches
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| 2014 25 March | | Serie B | Palermo | 1 - 1 | Robur Siena |
| 2013 21 October | | Serie B | Robur Siena | 2 - 3 | Palermo |
| 2013 10 March | | Serie A | Palermo | 1 - 2 | Robur Siena |
| 2012 27 October | | Serie A | Robur Siena | 0 - 0 | Palermo |
| 2012 26 February | | Serie A | Robur Siena | 4 - 1 | Palermo |
| 2011 13 December | | Cup | Palermo | 3 - 3 | Robur Siena |
| 2011 2 October | | Serie A | Palermo | 2 - 0 | Robur Siena |
| 2010 2 May | | Serie A | Robur Siena | 1 - 2 | Palermo |
| 2009 20 December | | Serie A | Palermo | 1 - 0 | Robur Siena |
| 2009 10 May | | Serie A | Robur Siena | 1 - 0 | Palermo |
| 2008 14 December | | Serie A | Palermo | 2 - 0 | Robur Siena |
| 2008 18 May | | Serie A | Robur Siena | 2 - 2 | Palermo |
| 2008 20 January | | Serie A | Palermo | 2 - 3 | Robur Siena |
| 2007 20 May | | Serie A | Palermo | 2 - 1 | Robur Siena |
| 2006 23 December | | Serie A | Robur Siena | 1 - 1 | Palermo |
| 2006 27 January | | Serie A | Palermo | 1 - 3 | Robur Siena |
| 2005 17 September | | Serie A | Robur Siena | 1 - 2 | Palermo |
| 2005 22 January | | Serie A | Robur Siena | 0 - 0 | Palermo |
| 2004 11 September | | Serie A | Palermo | 1 - 0 | Robur Siena |
| 2003 22 February | | Serie B | Robur Siena | 2 - 1 | Palermo |
| 2002 20 September | | Serie B | Palermo | 1 - 0 | Robur Siena |
| 2002 6 April | | Serie B | Palermo | 0 - 2 | Robur Siena |
| 2001 3 November | | Serie B | Robur Siena | 1 - 1 | Palermo |
Biggest Siena Victory vs Palermo
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| 2012 26 February | | Serie A | Robur Siena | 4 - 1 | Palermo |
Biggest Palermo Victory vs Siena
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| 2008 14 December | | Serie A | Palermo | 2 - 0 | Robur Siena |
Biggest Siena Defeat vs Palermo
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| 2008 14 December | | Serie A | Palermo | 2 - 0 | Robur Siena |
Biggest Palermo Defeat vs Siena
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| 2012 26 February | | Serie A | Robur Siena | 4 - 1 | Palermo |
Last 5 Siena Home Matches
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| 2023 23 April | | Serie C1 - A | Robur Siena | 1 - 2 | Virtus Entella |
| 2023 6 April | | Serie C1 - A | Robur Siena | 2 - 2 | Gubbio |
| 2023 18 March | | Serie C1 - A | Robur Siena | 0 - 0 | Alessandria |
| 2023 11 March | | Serie C1 - A | Robur Siena | 4 - 0 | Vis Pesaro |
| 2023 25 February | | Serie C1 - A | Robur Siena | 1 - 1 | Recanatese |
Last 5 Palermo Home Matches
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| 2024 3 November | | Serie B | Palermo | 0 - 1 | Cittadella |
| 2024 26 October | | Serie B | Palermo | 2 - 0 | Reggiana |
| 2024 6 October | | Serie B | Palermo | 0 - 1 | Salernitana |
| 2024 21 September | | Serie B | Palermo | 0 - 0 | Cesena |
| 2024 1 September | | Serie B | Palermo | 1 - 1 | Nuova Cosenza |
Last 5 Siena Away Matches
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| 2023 15 April | | Serie C1 - A | Fiorenzuola | 1 - 1 | Robur Siena |
| 2023 1 April | | Serie C1 - A | Fermana | 3 - 1 | Robur Siena |
| 2023 26 March | | Serie C1 - A | Carrarese | 3 - 0 | Robur Siena |
| 2023 14 March | | Serie C1 - A | Lucchese | 1 - 1 | Robur Siena |
| 2023 5 March | | Serie C1 - A | San Donato Tavarnelle | 1 - 1 | Robur Siena |
Last 5 Palermo Away Matches
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| 2024 8 November | | Serie B | Frosinone | 1 - 1 | Palermo |
| 2024 30 October | | Serie B | Mantova | 0 - 0 | Palermo |
| 2024 19 October | | Serie B | Modena | 2 - 2 | Palermo |
| 2024 30 September | | Serie B | Sudtirol | 1 - 3 | Palermo |
| 2024 26 September | | Cup | Napoli | 5 - 0 | Palermo |