This page lists the head-to-head record of Siena vs Sassuolo including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Sassuolo | Siena | Draws |
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| Total Matches | 2 | 1 | 1 | 0 |
| At Mapei Stadium | 1 | 0 | 1 | 0 |
| At Montepaschi Arena | 1 | 1 | 0 | 0 |
| Serie B Matches | 2 | 1 | 1 | 0 |
| Total Goals Scored | 11 | 4 | 7 | |
Last 50 Sassuolo vs Siena Matches
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| 2011 27 March | | Serie B | Robur Siena | 4 - 0 | Sassuolo |
| 2010 1 November | | Serie B | Sassuolo | 4 - 3 | Robur Siena |
Biggest Sassuolo Victory vs Siena
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| 2010 1 November | | Serie B | Sassuolo | 4 - 3 | Robur Siena |
Biggest Siena Victory vs Sassuolo
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| 2011 27 March | | Serie B | Robur Siena | 4 - 0 | Sassuolo |
Biggest Sassuolo Defeat vs Siena
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| 2011 27 March | | Serie B | Robur Siena | 4 - 0 | Sassuolo |
Biggest Siena Defeat vs Sassuolo
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| 2010 1 November | | Serie B | Sassuolo | 4 - 3 | Robur Siena |
Last 5 Sassuolo Home Matches
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| 2024 3 November | | Serie B | Sassuolo | 1 - 0 | Mantova |
| 2024 26 October | | Serie B | Sassuolo | 2 - 0 | Modena |
| 2024 5 October | | Serie B | Sassuolo | 6 - 1 | Cittadella |
| 2024 28 September | | Serie B | Sassuolo | 0 - 0 | Spezia |
| 2024 31 August | | Serie B | Sassuolo | 1 - 4 | Cremonese |
Last 5 Siena Home Matches
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| 2023 23 April | | Serie C1 - A | Robur Siena | 1 - 2 | Virtus Entella |
| 2023 6 April | | Serie C1 - A | Robur Siena | 2 - 2 | Gubbio |
| 2023 18 March | | Serie C1 - A | Robur Siena | 0 - 0 | Alessandria |
| 2023 11 March | | Serie C1 - A | Robur Siena | 4 - 0 | Vis Pesaro |
| 2023 25 February | | Serie C1 - A | Robur Siena | 1 - 1 | Recanatese |
Last 5 Sassuolo Away Matches
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| 2024 9 November | | Serie B | Sudtirol | 0 - 1 | Sassuolo |
| 2024 29 October | | Serie B | Juve Stabia | 2 - 2 | Sassuolo |
| 2024 19 October | | Serie B | Brescia | 2 - 5 | Sassuolo |
| 2024 24 September | | Cup | Lecce | 0 - 2 | Sassuolo |
| 2024 21 September | | Serie B | Nuova Cosenza | 0 - 1 | Sassuolo |
Last 5 Siena Away Matches
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| 2023 15 April | | Serie C1 - A | Fiorenzuola | 1 - 1 | Robur Siena |
| 2023 1 April | | Serie C1 - A | Fermana | 3 - 1 | Robur Siena |
| 2023 26 March | | Serie C1 - A | Carrarese | 3 - 0 | Robur Siena |
| 2023 14 March | | Serie C1 - A | Lucchese | 1 - 1 | Robur Siena |
| 2023 5 March | | Serie C1 - A | San Donato Tavarnelle | 1 - 1 | Robur Siena |