This page lists the head-to-head record of Palermo vs Sassuolo including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Sassuolo | Palermo | Draws |
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| Total Matches | 7 | 4 | 1 | 2 |
| At Mapei Stadium | 3 | 2 | 1 | 0 |
| At Stadio Renzo Barbera | 4 | 2 | 0 | 2 |
| Serie B Matches | 1 | 1 | 0 | 0 |
| Serie A Matches | 6 | 3 | 1 | 2 |
| Total Goals Scored | 17 | 11 | 6 | |
Last 50 Sassuolo vs Palermo Matches
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| 2024 21 December | | Serie B | Sassuolo | 2 - 1 | Palermo |
| 2017 15 January | | Serie A | Sassuolo | 4 - 1 | Palermo |
| 2016 21 August | | Serie A | Palermo | 0 - 1 | Sassuolo |
| 2016 7 February | | Serie A | Sassuolo | 2 - 2 | Palermo |
| 2015 23 September | | Serie A | Palermo | 0 - 1 | Sassuolo |
| 2015 2 May | | Serie A | Sassuolo | 0 - 0 | Palermo |
| 2014 13 December | | Serie A | Palermo | 2 - 1 | Sassuolo |
Biggest Sassuolo Victory vs Palermo
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| 2017 15 January | | Serie A | Sassuolo | 4 - 1 | Palermo |
Biggest Palermo Victory vs Sassuolo
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| 2014 13 December | | Serie A | Palermo | 2 - 1 | Sassuolo |
Biggest Sassuolo Defeat vs Palermo
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| 2014 13 December | | Serie A | Palermo | 2 - 1 | Sassuolo |
Biggest Palermo Defeat vs Sassuolo
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| 2017 15 January | | Serie A | Sassuolo | 4 - 1 | Palermo |
Last 5 Sassuolo Home Matches
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| 2025 29 March | | Serie B | Sassuolo | 5 - 1 | Reggiana |
| 2025 9 March | | Serie B | Sassuolo | 1 - 1 | Bari 1908 |
| 2025 1 March | | Serie B | Sassuolo | 1 - 0 | Pisa |
| 2025 15 February | | Serie B | Sassuolo | 2 - 0 | Brescia |
| 2025 1 February | | Serie B | Sassuolo | 2 - 0 | Juve Stabia |
Last 5 Palermo Home Matches
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| 2025 14 March | | Serie B | Palermo | 2 - 3 | Cremonese |
| 2025 2 March | | Serie B | Palermo | 1 - 0 | Brescia |
| 2025 16 February | | Serie B | Palermo | 2 - 2 | Mantova |
| 2025 31 January | | Serie B | Palermo | 1 - 2 | Pisa |
| 2025 19 January | | Serie B | Palermo | 1 - 0 | Juve Stabia |
Last 5 Sassuolo Away Matches
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| 2025 15 March | | Serie B | Cittadella | 1 - 2 | Sassuolo |
| 2025 21 February | | Serie B | Sampdoria | 0 - 0 | Sassuolo |
| 2025 8 February | | Serie B | Mantova | 0 - 3 | Sassuolo |
| 2025 24 January | | Serie B | Spezia | 2 - 1 | Sassuolo |
| 2025 12 January | | Serie B | Salernitana | 1 - 2 | Sassuolo |
Last 5 Palermo Away Matches
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| 2025 30 March | | Serie B | Salernitana | 1 - 2 | Palermo |
| 2025 8 March | | Serie B | Sampdoria | 1 - 1 | Palermo |
| 2025 23 February | | Serie B | Nuova Cosenza | 0 - 3 | Palermo |
| 2025 9 February | | Serie B | Spezia | 2 - 2 | Palermo |
| 2025 26 January | | Serie B | Reggiana | 2 - 1 | Palermo |