This page lists the head-to-head record of Vitoria Guimaraes vs Santa Clara including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Santa Clara | Vitoria Guimaraes | Draws |
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| Total Matches | 22 | 7 | 13 | 2 |
| At Estadio de Sao Miguel | 12 | 1 | 10 | 1 |
| At D. Afonso Henriques | 10 | 6 | 3 | 1 |
| Division2 Matches | 2 | 0 | 2 | 0 |
| Cup Matches | 1 | 1 | 0 | 0 |
| Portuguese Liga Matches | 19 | 6 | 11 | 2 |
| Total Goals Scored | 49 | 17 | 32 | |
Last 50 Santa Clara vs Vitoria Guimaraes Matches
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| 2025 4 October | | Portuguese Liga | Guimaraes | 2 - 1 | Santa Clara |
| 2025 5 April | | Portuguese Liga | Guimaraes | 2 - 0 | Santa Clara |
| 2024 10 November | | Portuguese Liga | Santa Clara | 1 - 0 | Guimaraes |
| 2023 5 March | | Portuguese Liga | Santa Clara | 1 - 3 | Guimaraes |
| 2022 9 September | | Portuguese Liga | Guimaraes | 1 - 0 | Santa Clara |
| 2022 1 May | | Portuguese Liga | Guimaraes | 1 - 1 | Santa Clara |
| 2021 17 December | | Portuguese Liga | Santa Clara | 1 - 0 | Guimaraes |
| 2021 17 April | | Portuguese Liga | Guimaraes | 1 - 0 | Santa Clara |
| 2020 21 December | | Portuguese Liga | Santa Clara | 0 - 4 | Guimaraes |
| 2020 13 December | | Cup | Guimaraes | 0 - 1 | Santa Clara |
| 2020 24 July | | Portuguese Liga | Santa Clara | 2 - 2 | Guimaraes |
| 2020 18 January | | Portuguese Liga | Guimaraes | 1 - 0 | Santa Clara |
| 2019 30 March | | Portuguese Liga | Santa Clara | 1 - 0 | Guimaraes |
| 2018 11 November | | Portuguese Liga | Guimaraes | 2 - 0 | Santa Clara |
| 2007 17 March | | Division2 | Santa Clara | 0 - 1 | Guimaraes |
| 2006 21 October | | Division2 | Guimaraes | 1 - 0 | Santa Clara |
| 2003 22 February | | Portuguese Liga | Santa Clara | 2 - 1 | Guimaraes |
| 2002 5 October | | Portuguese Liga | Guimaraes | 5 - 0 | Santa Clara |
| 2002 7 February | | Portuguese Liga | Guimaraes | 1 - 0 | Santa Clara |
| 2001 15 September | | Portuguese Liga | Santa Clara | 2 - 0 | Guimaraes |
| 2000 13 May | | Portuguese Liga | Santa Clara | 3 - 2 | Guimaraes |
| 2000 15 January | | Portuguese Liga | Guimaraes | 2 - 1 | Santa Clara |
Biggest Santa Clara Victory vs Vitoria Guimaraes
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| 2001 15 September | | Portuguese Liga | Santa Clara | 2 - 0 | Guimaraes |
Biggest Vitoria Guimaraes Victory vs Santa Clara
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| 2002 5 October | | Portuguese Liga | Guimaraes | 5 - 0 | Santa Clara |
Biggest Santa Clara Defeat vs Vitoria Guimaraes
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| 2002 5 October | | Portuguese Liga | Guimaraes | 5 - 0 | Santa Clara |
Biggest Vitoria Guimaraes Defeat vs Santa Clara
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| 2001 15 September | | Portuguese Liga | Santa Clara | 2 - 0 | Guimaraes |
Last 5 Santa Clara Home Matches
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| 2026 13 February | | Portuguese Liga | Santa Clara | 1 - 2 | Benfica |
| 2026 31 January | | Portuguese Liga | Santa Clara | 2 - 4 | Estoril |
| 2026 18 January | | Portuguese Liga | Santa Clara | 0 - 1 | Famalicao |
| 2026 4 January | | Portuguese Liga | Santa Clara | 0 - 1 | Porto |
| 2025 21 December | | Portuguese Liga | Santa Clara | 0 - 0 | Arouca |
Last 5 Vitoria Guimaraes Home Matches
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| 2026 14 February | | Portuguese Liga | Guimaraes | 2 - 1 | Estrela P |
| 2026 30 January | | Portuguese Liga | Guimaraes | 1 - 0 | Moreirense |
| 2026 18 January | | Portuguese Liga | Guimaraes | 0 - 1 | Porto |
| 2026 2 January | | Portuguese Liga | Guimaraes | 2 - 1 | Nacional |
| 2025 23 December | | Portuguese Liga | Guimaraes | 1 - 4 | Sporting Lisbon |
Last 5 Santa Clara Away Matches
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| 2026 7 February | | Portuguese Liga | Estrela P | 1 - 0 | Santa Clara |
| 2026 24 January | | Portuguese Liga | Moreirense | 1 - 0 | Santa Clara |
| 2026 11 January | | Portuguese Liga | Nacional | 3 - 3 | Santa Clara |
| 2025 15 December | | Portuguese Liga | Sporting Braga | 1 - 0 | Santa Clara |
| 2025 30 November | | Portuguese Liga | Rio Ave | 1 - 1 | Santa Clara |
Last 5 Vitoria Guimaraes Away Matches
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| 2026 7 February | | Portuguese Liga | Arouca | 3 - 2 | Guimaraes |
| 2026 24 January | | Portuguese Liga | Estoril | 4 - 2 | Guimaraes |
| 2025 28 December | | Portuguese Liga | Casa Pia | 0 - 0 | Guimaraes |
| 2025 13 December | | Portuguese Liga | Rio Ave | 0 - 1 | Guimaraes |
| 2025 8 November | | Portuguese Liga | Tondela | 0 - 1 | Guimaraes |