This page lists the head-to-head record of Siena vs Sampdoria including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Sampdoria | Siena | Draws |
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| Total Matches | 22 | 8 | 5 | 9 |
| At Luigi Ferraris | 11 | 4 | 4 | 3 |
| At Montepaschi Arena | 11 | 4 | 1 | 6 |
| Serie B Matches | 6 | 1 | 2 | 3 |
| Serie A Matches | 16 | 7 | 3 | 6 |
| Total Goals Scored | 45 | 27 | 18 | |
Last 50 Sampdoria vs Siena Matches
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| 2013 20 January | | Serie A | Robur Siena | 1 - 0 | Sampdoria |
| 2012 2 September | | Serie A | Sampdoria | 2 - 1 | Robur Siena |
| 2010 7 February | | Serie A | Robur Siena | 1 - 2 | Sampdoria |
| 2009 20 September | | Serie A | Sampdoria | 4 - 1 | Robur Siena |
| 2009 8 February | | Serie A | Sampdoria | 2 - 2 | Robur Siena |
| 2008 24 September | | Serie A | Robur Siena | 0 - 0 | Sampdoria |
| 2008 26 January | | Serie A | Sampdoria | 1 - 0 | Robur Siena |
| 2007 26 August | | Serie A | Robur Siena | 1 - 2 | Sampdoria |
| 2007 29 April | | Serie A | Robur Siena | 0 - 2 | Sampdoria |
| 2006 10 December | | Serie A | Sampdoria | 0 - 0 | Robur Siena |
| 2006 25 February | | Serie A | Robur Siena | 1 - 0 | Sampdoria |
| 2005 22 October | | Serie A | Sampdoria | 3 - 3 | Robur Siena |
| 2005 29 January | | Serie A | Sampdoria | 1 - 1 | Robur Siena |
| 2004 18 September | | Serie A | Robur Siena | 2 - 1 | Sampdoria |
| 2004 9 April | | Serie A | Robur Siena | 0 - 0 | Sampdoria |
| 2003 6 December | | Serie A | Sampdoria | 2 - 1 | Robur Siena |
| 2003 27 April | | Serie B | Sampdoria | 0 - 0 | Robur Siena |
| 2002 23 November | | Serie B | Robur Siena | 1 - 0 | Sampdoria |
| 2002 1 June | | Serie B | Sampdoria | 0 - 1 | Robur Siena |
| 2002 5 January | | Serie B | Robur Siena | 0 - 4 | Sampdoria |
| 2001 29 April | | Serie B | Robur Siena | 0 - 0 | Sampdoria |
| 2000 2 December | | Serie B | Sampdoria | 1 - 1 | Robur Siena |
Biggest Sampdoria Victory vs Siena
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| 2002 5 January | | Serie B | Robur Siena | 0 - 4 | Sampdoria |
Biggest Siena Victory vs Sampdoria
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| 2006 25 February | | Serie A | Robur Siena | 1 - 0 | Sampdoria |
Biggest Sampdoria Defeat vs Siena
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| 2006 25 February | | Serie A | Robur Siena | 1 - 0 | Sampdoria |
Biggest Siena Defeat vs Sampdoria
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| 2002 5 January | | Serie B | Robur Siena | 0 - 4 | Sampdoria |
Last 5 Sampdoria Home Matches
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| 2025 25 October | | Serie B | Sampdoria | 1 - 1 | Frosinone |
| 2025 5 October | | Serie B | Sampdoria | 4 - 1 | Pescara |
| 2025 1 October | | Serie B | Sampdoria | 0 - 0 | Catanzaro |
| 2025 13 September | | Serie B | Sampdoria | 1 - 2 | Cesena |
| 2025 25 August | | Serie B | Sampdoria | 0 - 2 | Modena |
Last 5 Siena Home Matches
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| 2023 23 April | | Serie C1 - A | Robur Siena | 1 - 2 | Virtus Entella |
| 2023 6 April | | Serie C1 - A | Robur Siena | 2 - 2 | Gubbio |
| 2023 18 March | | Serie C1 - A | Robur Siena | 0 - 0 | Alessandria |
| 2023 11 March | | Serie C1 - A | Robur Siena | 4 - 0 | Vis Pesaro |
| 2023 25 February | | Serie C1 - A | Robur Siena | 1 - 1 | Recanatese |
Last 5 Sampdoria Away Matches
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| 2025 17 October | | Serie B | Virtus Entella | 3 - 1 | Sampdoria |
| 2025 27 September | | Serie B | Bari 1908 | 1 - 1 | Sampdoria |
| 2025 20 September | | Serie B | Monza | 1 - 0 | Sampdoria |
| 2025 31 August | | Serie B | Sudtirol | 3 - 1 | Sampdoria |
| 2025 18 August | | Cup | Spezia | 1 - 1 | Sampdoria |
Last 5 Siena Away Matches
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| 2023 15 April | | Serie C1 - A | Fiorenzuola | 1 - 1 | Robur Siena |
| 2023 1 April | | Serie C1 - A | Fermana | 3 - 1 | Robur Siena |
| 2023 26 March | | Serie C1 - A | Carrarese | 3 - 0 | Robur Siena |
| 2023 14 March | | Serie C1 - A | Lucchese | 1 - 1 | Robur Siena |
| 2023 5 March | | Serie C1 - A | San Donato Tavarnelle | 1 - 1 | Robur Siena |