This page lists the head-to-head record of Roma vs Sampdoria including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Sampdoria | Roma | Draws |
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| Total Matches | 54 | 13 | 27 | 14 |
| At Luigi Ferraris | 28 | 5 | 19 | 4 |
| At Stadio Olimpico | 26 | 8 | 8 | 10 |
| Cup Matches | 4 | 0 | 3 | 1 |
| Serie A Matches | 50 | 13 | 24 | 13 |
| Total Goals Scored | 132 | 51 | 81 | |
Last 50 Sampdoria vs Roma Matches
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| 2023 2 April | | Serie A | Roma | 3 - 0 | Sampdoria |
| 2022 17 October | | Serie A | Sampdoria | 0 - 1 | Roma |
| 2022 3 April | | Serie A | Sampdoria | 0 - 1 | Roma |
| 2021 22 December | | Serie A | Roma | 1 - 1 | Sampdoria |
| 2021 2 May | | Serie A | Sampdoria | 2 - 0 | Roma |
| 2021 3 January | | Serie A | Roma | 1 - 0 | Sampdoria |
| 2020 24 June | | Serie A | Roma | 2 - 1 | Sampdoria |
| 2019 20 October | | Serie A | Sampdoria | 0 - 0 | Roma |
| 2019 6 April | | Serie A | Sampdoria | 0 - 1 | Roma |
| 2018 11 November | | Serie A | Roma | 4 - 1 | Sampdoria |
| 2018 28 January | | Serie A | Roma | 0 - 1 | Sampdoria |
| 2018 24 January | | Serie A | Sampdoria | 1 - 1 | Roma |
| 2017 29 January | | Serie A | Sampdoria | 3 - 2 | Roma |
| 2017 19 January | | Cup | Roma | 4 - 0 | Sampdoria |
| 2016 11 September | | Serie A | Roma | 3 - 2 | Sampdoria |
| 2016 7 February | | Serie A | Roma | 2 - 1 | Sampdoria |
| 2015 23 September | | Serie A | Sampdoria | 2 - 1 | Roma |
| 2015 16 March | | Serie A | Roma | 0 - 2 | Sampdoria |
| 2014 25 October | | Serie A | Sampdoria | 0 - 0 | Roma |
| 2014 16 February | | Serie A | Roma | 3 - 0 | Sampdoria |
| 2014 9 January | | Cup | Roma | 1 - 0 | Sampdoria |
| 2013 25 September | | Serie A | Sampdoria | 0 - 2 | Roma |
| 2013 10 February | | Serie A | Sampdoria | 3 - 1 | Roma |
| 2012 26 September | | Serie A | Roma | 1 - 1 | Sampdoria |
| 2011 22 May | | Serie A | Roma | 3 - 1 | Sampdoria |
| 2011 9 January | | Serie A | Sampdoria | 2 - 1 | Roma |
| 2010 25 April | | Serie A | Roma | 1 - 2 | Sampdoria |
| 2009 13 December | | Serie A | Sampdoria | 0 - 0 | Roma |
| 2009 15 March | | Serie A | Sampdoria | 2 - 2 | Roma |
| 2009 14 January | | Serie A | Roma | 2 - 0 | Sampdoria |
| 2008 4 May | | Serie A | Sampdoria | 0 - 3 | Roma |
| 2008 29 January | | Cup | Roma | 1 - 0 | Sampdoria |
| 2008 23 January | | Cup | Sampdoria | 1 - 1 | Roma |
| 2007 22 December | | Serie A | Roma | 2 - 0 | Sampdoria |
| 2007 15 April | | Serie A | Roma | 4 - 0 | Sampdoria |
| 2006 26 November | | Serie A | Sampdoria | 2 - 4 | Roma |
| 2006 21 April | | Serie A | Roma | 0 - 0 | Sampdoria |
| 2005 17 December | | Serie A | Sampdoria | 1 - 1 | Roma |
| 2005 23 April | | Serie A | Sampdoria | 2 - 1 | Roma |
| 2004 4 December | | Serie A | Roma | 1 - 1 | Sampdoria |
| 2004 15 May | | Serie A | Sampdoria | 0 - 0 | Roma |
| 2004 17 January | | Serie A | Roma | 3 - 1 | Sampdoria |
| 1999 13 February | | Serie A | Roma | 3 - 1 | Sampdoria |
| 1998 3 October | | Serie A | Sampdoria | 2 - 1 | Roma |
| 1998 15 May | | Serie A | Roma | 2 - 0 | Sampdoria |
| 1998 24 January | | Serie A | Sampdoria | 1 - 1 | Roma |
| 1997 15 February | | Serie A | Sampdoria | 1 - 2 | Roma |
| 1996 21 September | | Serie A | Roma | 1 - 4 | Sampdoria |
| 1996 20 January | | Serie A | Roma | 3 - 1 | Sampdoria |
| 1995 26 August | | Serie A | Sampdoria | 1 - 1 | Roma |
Biggest Sampdoria Victory vs Roma
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| 1996 21 September | | Serie A | Roma | 1 - 4 | Sampdoria |
Biggest Roma Victory vs Sampdoria
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| 2017 19 January | | Cup | Roma | 4 - 0 | Sampdoria |
Biggest Sampdoria Defeat vs Roma
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| 2017 19 January | | Cup | Roma | 4 - 0 | Sampdoria |
Biggest Roma Defeat vs Sampdoria
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| 1996 21 September | | Serie A | Roma | 1 - 4 | Sampdoria |
Last 5 Sampdoria Home Matches
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| 2024 13 April | | Serie B | Sampdoria | 0 - 1 | Sudtirol |
| 2024 1 April | | Serie B | Sampdoria | 4 - 1 | Ternana |
| 2024 11 March | | Serie B | Sampdoria | 2 - 1 | Ascoli Picchio |
| 2024 27 February | | Serie B | Sampdoria | 1 - 2 | Cremonese |
| 2024 17 February | | Serie B | Sampdoria | 1 - 1 | Brescia |
Last 5 Roma Home Matches
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| 2024 22 April | | Serie A | Roma | 1 - 3 | Bologna |
| 2024 18 April | | UEFA Europa League | Roma | 2 - 1 | Milan |
| 2024 6 April | | Serie A | Roma | 1 - 0 | Lazio |
| 2024 17 March | | Serie A | Roma | 1 - 0 | Sassuolo |
| 2024 7 March | | UEFA Europa League | Roma | 4 - 0 | Brighton & Hove Albion |
Last 5 Sampdoria Away Matches
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| 2024 20 April | | Serie B | Spezia | 0 - 0 | Sampdoria |
| 2024 6 April | | Serie B | Palermo | 2 - 2 | Sampdoria |
| 2024 16 March | | Serie B | Bari 1908 | 0 - 1 | Sampdoria |
| 2024 3 March | | Serie B | FeralpiSalo | 1 - 3 | Sampdoria |
| 2024 23 February | | Serie B | Nuova Cosenza | 1 - 2 | Sampdoria |
Last 5 Roma Away Matches
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| 2024 11 April | | UEFA Europa League | Milan | 0 - 1 | Roma |
| 2024 1 April | | Serie A | Lecce | 0 - 0 | Roma |
| 2024 14 March | | UEFA Europa League | Brighton & Hove Albion | 1 - 0 | Roma |
| 2024 10 March | | Serie A | Fiorentina | 2 - 2 | Roma |
| 2024 2 March | | Serie A | Monza | 1 - 4 | Roma |