This page lists the head-to-head record of Palermo vs Sampdoria including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Sampdoria | Palermo | Draws |
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| Total Matches | 31 | 9 | 12 | 10 |
| At Luigi Ferraris | 16 | 3 | 7 | 6 |
| At Stadio Renzo Barbera | 15 | 6 | 5 | 4 |
| Cup Matches | 2 | 2 | 0 | 0 |
| Serie B Matches | 7 | 2 | 3 | 2 |
| Serie A Matches | 22 | 5 | 9 | 8 |
| Total Goals Scored | 69 | 30 | 39 | |
Last 50 Sampdoria vs Palermo Matches
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| 2024 17 May | | Serie B | Palermo | 2 - 0 | Sampdoria |
| 2024 6 April | | Serie B | Palermo | 2 - 2 | Sampdoria |
| 2023 4 November | | Serie B | Sampdoria | 1 - 0 | Palermo |
| 2017 26 February | | Serie A | Palermo | 1 - 1 | Sampdoria |
| 2016 2 October | | Serie A | Sampdoria | 1 - 1 | Palermo |
| 2016 1 May | | Serie A | Palermo | 2 - 0 | Sampdoria |
| 2015 20 December | | Serie A | Sampdoria | 2 - 0 | Palermo |
| 2015 25 January | | Serie A | Sampdoria | 1 - 1 | Palermo |
| 2014 31 August | | Serie A | Palermo | 1 - 1 | Sampdoria |
| 2013 7 April | | Serie A | Sampdoria | 1 - 3 | Palermo |
| 2012 11 November | | Serie A | Palermo | 2 - 0 | Sampdoria |
| 2011 15 May | | Serie A | Sampdoria | 1 - 2 | Palermo |
| 2011 6 January | | Serie A | Palermo | 3 - 0 | Sampdoria |
| 2010 9 May | | Serie A | Palermo | 1 - 1 | Sampdoria |
| 2010 6 January | | Serie A | Sampdoria | 1 - 1 | Palermo |
| 2009 31 May | | Serie A | Palermo | 2 - 2 | Sampdoria |
| 2009 18 January | | Serie A | Sampdoria | 0 - 2 | Palermo |
| 2008 11 May | | Serie A | Palermo | 0 - 2 | Sampdoria |
| 2008 13 January | | Serie A | Sampdoria | 3 - 0 | Palermo |
| 2007 17 March | | Serie A | Sampdoria | 1 - 1 | Palermo |
| 2006 29 November | | Cup | Palermo | 2 - 3 | Sampdoria |
| 2006 7 November | | Cup | Sampdoria | 1 - 0 | Palermo |
| 2006 5 November | | Serie A | Palermo | 2 - 0 | Sampdoria |
| 2006 18 March | | Serie A | Sampdoria | 0 - 2 | Palermo |
| 2005 5 November | | Serie A | Palermo | 0 - 2 | Sampdoria |
| 2005 15 April | | Serie A | Sampdoria | 1 - 0 | Palermo |
| 2004 13 November | | Serie A | Palermo | 2 - 0 | Sampdoria |
| 2003 1 February | | Serie B | Sampdoria | 1 - 0 | Palermo |
| 2003 5 January | | Serie B | Palermo | 0 - 0 | Sampdoria |
| 2002 23 February | | Serie B | Palermo | 2 - 0 | Sampdoria |
| 2001 29 September | | Serie B | Sampdoria | 1 - 2 | Palermo |
Biggest Sampdoria Victory vs Palermo
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| 2008 13 January | | Serie A | Sampdoria | 3 - 0 | Palermo |
Biggest Palermo Victory vs Sampdoria
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| 2011 6 January | | Serie A | Palermo | 3 - 0 | Sampdoria |
Biggest Sampdoria Defeat vs Palermo
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| 2011 6 January | | Serie A | Palermo | 3 - 0 | Sampdoria |
Biggest Palermo Defeat vs Sampdoria
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| 2008 13 January | | Serie A | Sampdoria | 3 - 0 | Palermo |
Last 5 Sampdoria Home Matches
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| 2024 3 November | | Serie B | Sampdoria | 0 - 1 | Brescia |
| 2024 27 October | | Serie B | Sampdoria | 1 - 0 | Mantova |
| 2024 4 October | | Serie B | Sampdoria | 1 - 2 | Juve Stabia |
| 2024 21 September | | Serie B | Sampdoria | 1 - 0 | Sudtirol |
| 2024 31 August | | Serie B | Sampdoria | 0 - 0 | Bari 1908 |
Last 5 Palermo Home Matches
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| 2024 3 November | | Serie B | Palermo | 0 - 1 | Cittadella |
| 2024 26 October | | Serie B | Palermo | 2 - 0 | Reggiana |
| 2024 6 October | | Serie B | Palermo | 0 - 1 | Salernitana |
| 2024 21 September | | Serie B | Palermo | 0 - 0 | Cesena |
| 2024 1 September | | Serie B | Palermo | 1 - 1 | Nuova Cosenza |
Last 5 Sampdoria Away Matches
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| 2024 9 November | | Serie B | Pisa | 3 - 0 | Sampdoria |
| 2024 30 October | | Serie B | Cittadella | 0 - 0 | Sampdoria |
| 2024 20 October | | Serie B | Cesena | 3 - 5 | Sampdoria |
| 2024 29 September | | Serie B | Modena | 1 - 3 | Sampdoria |
| 2024 25 September | | Cup | Genoa | 1 - 1 | Sampdoria |
Last 5 Palermo Away Matches
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| 2024 8 November | | Serie B | Frosinone | 1 - 1 | Palermo |
| 2024 30 October | | Serie B | Mantova | 0 - 0 | Palermo |
| 2024 19 October | | Serie B | Modena | 2 - 2 | Palermo |
| 2024 30 September | | Serie B | Sudtirol | 1 - 3 | Palermo |
| 2024 26 September | | Cup | Napoli | 5 - 0 | Palermo |