This page lists the head-to-head record of Empoli vs Sampdoria including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Sampdoria | Empoli | Draws |
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| Total Matches | 34 | 15 | 11 | 8 |
| At Luigi Ferraris | 17 | 6 | 7 | 4 |
| At Stadio Carlo Castellani | 17 | 9 | 4 | 4 |
| Cup Matches | 2 | 1 | 1 | 0 |
| Serie B Matches | 8 | 2 | 4 | 2 |
| Serie A Matches | 24 | 12 | 6 | 6 |
| Total Goals Scored | 75 | 44 | 31 | |
Last 50 Sampdoria vs Empoli Matches
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| 2023 15 May | | Serie A | Sampdoria | 1 - 1 | Empoli |
| 2023 16 January | | Serie A | Empoli | 1 - 0 | Sampdoria |
| 2022 19 February | | Serie A | Sampdoria | 2 - 0 | Empoli |
| 2021 19 September | | Serie A | Empoli | 0 - 3 | Sampdoria |
| 2019 12 May | | Serie A | Sampdoria | 1 - 2 | Empoli |
| 2018 22 December | | Serie A | Empoli | 2 - 4 | Sampdoria |
| 2017 15 January | | Serie A | Sampdoria | 0 - 0 | Empoli |
| 2016 21 August | | Serie A | Empoli | 0 - 1 | Sampdoria |
| 2016 12 March | | Serie A | Empoli | 1 - 1 | Sampdoria |
| 2015 29 October | | Serie A | Sampdoria | 1 - 1 | Empoli |
| 2015 24 May | | Serie A | Empoli | 1 - 1 | Sampdoria |
| 2015 11 January | | Serie A | Sampdoria | 1 - 0 | Empoli |
| 2012 6 March | | Serie B | Sampdoria | 1 - 0 | Empoli |
| 2011 12 September | | Serie B | Empoli | 1 - 3 | Sampdoria |
| 2011 20 August | | Cup | Empoli | 2 - 1 | Sampdoria |
| 2008 12 November | | Cup | Sampdoria | 2 - 1 | Empoli |
| 2008 30 March | | Serie A | Empoli | 0 - 2 | Sampdoria |
| 2007 10 November | | Serie A | Sampdoria | 3 - 0 | Empoli |
| 2007 21 January | | Serie A | Empoli | 2 - 0 | Sampdoria |
| 2006 9 September | | Serie A | Sampdoria | 1 - 2 | Empoli |
| 2006 8 April | | Serie A | Empoli | 2 - 1 | Sampdoria |
| 2005 3 December | | Serie A | Sampdoria | 2 - 0 | Empoli |
| 2004 20 March | | Serie A | Empoli | 1 - 1 | Sampdoria |
| 2003 7 November | | Serie A | Sampdoria | 2 - 0 | Empoli |
| 2002 9 February | | Serie B | Empoli | 2 - 0 | Sampdoria |
| 2001 15 September | | Serie B | Sampdoria | 0 - 2 | Empoli |
| 2001 1 March | | Serie B | Empoli | 0 - 0 | Sampdoria |
| 2000 7 October | | Serie B | Sampdoria | 0 - 1 | Empoli |
| 2000 12 February | | Serie B | Sampdoria | 1 - 1 | Empoli |
| 1999 11 September | | Serie B | Empoli | 1 - 0 | Sampdoria |
| 1999 27 February | | Serie A | Empoli | 0 - 1 | Sampdoria |
| 1998 24 October | | Serie A | Sampdoria | 3 - 0 | Empoli |
| 1998 10 April | | Serie A | Sampdoria | 3 - 0 | Empoli |
| 1997 13 December | | Serie A | Empoli | 4 - 1 | Sampdoria |
Biggest Sampdoria Victory vs Empoli
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| 2021 19 September | | Serie A | Empoli | 0 - 3 | Sampdoria |
Biggest Empoli Victory vs Sampdoria
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| 1997 13 December | | Serie A | Empoli | 4 - 1 | Sampdoria |
Biggest Sampdoria Defeat vs Empoli
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| 1997 13 December | | Serie A | Empoli | 4 - 1 | Sampdoria |
Biggest Empoli Defeat vs Sampdoria
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| 2021 19 September | | Serie A | Empoli | 0 - 3 | Sampdoria |
Last 5 Sampdoria Home Matches
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| 2024 3 November | | Serie B | Sampdoria | 0 - 1 | Brescia |
| 2024 27 October | | Serie B | Sampdoria | 1 - 0 | Mantova |
| 2024 4 October | | Serie B | Sampdoria | 1 - 2 | Juve Stabia |
| 2024 21 September | | Serie B | Sampdoria | 1 - 0 | Sudtirol |
| 2024 31 August | | Serie B | Sampdoria | 0 - 0 | Bari 1908 |
Last 5 Empoli Home Matches
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| 2024 4 November | | Serie A | Empoli | 1 - 0 | Como |
| 2024 30 October | | Serie A | Empoli | 0 - 3 | Internazionale |
| 2024 20 October | | Serie A | Empoli | 0 - 1 | Napoli |
| 2024 29 September | | Serie A | Empoli | 0 - 0 | Fiorentina |
| 2024 14 September | | Serie A | Empoli | 0 - 0 | Juventus |
Last 5 Sampdoria Away Matches
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| 2024 9 November | | Serie B | Pisa | 3 - 0 | Sampdoria |
| 2024 30 October | | Serie B | Cittadella | 0 - 0 | Sampdoria |
| 2024 20 October | | Serie B | Cesena | 3 - 5 | Sampdoria |
| 2024 29 September | | Serie B | Modena | 1 - 3 | Sampdoria |
| 2024 25 September | | Cup | Genoa | 1 - 1 | Sampdoria |
Last 5 Empoli Away Matches
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| 2024 8 November | | Serie A | Lecce | 1 - 1 | Empoli |
| 2024 27 October | | Serie A | Parma | 1 - 1 | Empoli |
| 2024 6 October | | Serie A | Lazio | 2 - 1 | Empoli |
| 2024 24 September | | Cup | Torino | 1 - 2 | Empoli |
| 2024 20 September | | Serie A | Cagliari | 0 - 2 | Empoli |