This page lists the head-to-head record of FC Twente vs PSV Eindhoven including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | PSV Eindhoven | FC Twente | Draws |
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| Total Matches | 66 | 35 | 8 | 23 |
| At Philips Stadion | 33 | 11 | 6 | 16 |
| At De Grolsch Veste | 33 | 24 | 2 | 7 |
| Cup Matches | 4 | 3 | 0 | 1 |
| Eredivisie Matches | 62 | 32 | 8 | 22 |
| Total Goals Scored | 199 | 129 | 70 | |
Last 50 PSV Eindhoven vs FC Twente Matches
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| 2025 24 April | | Eredivisie | Twente | 1 - 3 | PSV |
| 2024 6 December | | Eredivisie | PSV | 6 - 1 | Twente |
| 2024 17 March | | Eredivisie | PSV | 1 - 0 | Twente |
| 2024 17 January | | Cup | PSV | 3 - 1 | Twente |
| 2023 25 November | | Eredivisie | Twente | 0 - 3 | PSV |
| 2023 26 February | | Eredivisie | PSV | 3 - 1 | Twente |
| 2022 3 September | | Eredivisie | Twente | 2 - 1 | PSV |
| 2022 2 April | | Eredivisie | Twente | 3 - 3 | PSV |
| 2021 30 October | | Eredivisie | PSV | 5 - 2 | Twente |
| 2021 6 February | | Eredivisie | PSV | 3 - 0 | Twente |
| 2020 22 November | | Eredivisie | Twente | 1 - 1 | PSV |
| 2020 26 January | | Eredivisie | PSV | 1 - 1 | Twente |
| 2019 3 August | | Eredivisie | Twente | 1 - 1 | PSV |
| 2018 27 January | | Eredivisie | Twente | 0 - 2 | PSV |
| 2017 5 November | | Eredivisie | PSV | 4 - 3 | Twente |
| 2017 6 April | | Eredivisie | Twente | 2 - 2 | PSV |
| 2016 5 November | | Eredivisie | PSV | 1 - 1 | Twente |
| 2016 24 January | | Eredivisie | PSV | 4 - 2 | Twente |
| 2015 24 October | | Eredivisie | Twente | 1 - 3 | PSV |
| 2015 4 April | | Eredivisie | Twente | 0 - 5 | PSV |
| 2014 14 December | | Eredivisie | PSV | 2 - 0 | Twente |
| 2014 8 February | | Eredivisie | PSV | 3 - 2 | Twente |
| 2013 14 September | | Eredivisie | Twente | 2 - 2 | PSV |
| 2013 12 May | | Eredivisie | Twente | 3 - 1 | PSV |
| 2012 9 December | | Eredivisie | PSV | 3 - 0 | Twente |
| 2012 4 March | | Eredivisie | PSV | 2 - 6 | Twente |
| 2011 22 December | | Cup | Twente | 1 - 2 | PSV |
| 2011 29 October | | Eredivisie | Twente | 2 - 2 | PSV |
| 2011 2 April | | Eredivisie | Twente | 2 - 0 | PSV |
| 2011 26 January | | Cup | Twente | 1 - 1 | PSV |
| 2010 30 October | | Eredivisie | PSV | 0 - 1 | Twente |
| 2010 20 March | | Eredivisie | PSV | 1 - 1 | Twente |
| 2009 9 August | | Eredivisie | Twente | 1 - 1 | PSV |
| 2009 8 March | | Eredivisie | Twente | 1 - 1 | PSV |
| 2008 27 December | | Eredivisie | PSV | 0 - 0 | Twente |
| 2008 13 April | | Eredivisie | PSV | 1 - 1 | Twente |
| 2007 1 September | | Eredivisie | Twente | 0 - 0 | PSV |
| 2007 14 April | | Eredivisie | PSV | 2 - 0 | Twente |
| 2006 26 August | | Eredivisie | Twente | 1 - 0 | PSV |
| 2005 28 December | | Eredivisie | PSV | 1 - 1 | Twente |
| 2005 19 December | | Cup | PSV | 3 - 0 | Twente |
| 2005 28 October | | Eredivisie | Twente | 0 - 1 | PSV |
| 2005 28 April | | Eredivisie | Twente | 2 - 2 | PSV |
| 2004 26 November | | Eredivisie | PSV | 2 - 0 | Twente |
| 2004 13 February | | Eredivisie | PSV | 1 - 0 | Twente |
| 2003 29 August | | Eredivisie | Twente | 0 - 2 | PSV |
| 2003 18 April | | Eredivisie | PSV | 2 - 0 | Twente |
| 2002 1 November | | Eredivisie | Twente | 0 - 0 | PSV |
| 2002 19 April | | Eredivisie | Twente | 1 - 1 | PSV |
| 2001 8 December | | Eredivisie | PSV | 1 - 0 | Twente |
Biggest PSV Eindhoven Victory vs FC Twente
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| 2015 4 April | | Eredivisie | Twente | 0 - 5 | PSV |
Biggest FC Twente Victory vs PSV Eindhoven
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| 2012 4 March | | Eredivisie | PSV | 2 - 6 | Twente |
Biggest PSV Eindhoven Defeat vs FC Twente
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| 2012 4 March | | Eredivisie | PSV | 2 - 6 | Twente |
Biggest FC Twente Defeat vs PSV Eindhoven
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| 2015 4 April | | Eredivisie | Twente | 0 - 5 | PSV |
Last 5 PSV Eindhoven Home Matches
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| 2025 3 May | | Eredivisie | PSV | 4 - 1 | Fortuna Sittard |
| 2025 12 April | | Eredivisie | PSV | 5 - 0 | Almere City |
| 2025 30 March | | Eredivisie | PSV | 0 - 2 | Ajax |
| 2025 8 March | | Eredivisie | PSV | 2 - 1 | Heerenveen |
| 2025 4 March | | UEFA Champions League | PSV | 1 - 7 | Arsenal |
Last 5 FC Twente Home Matches
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| 2025 24 April | | Eredivisie | Twente | 1 - 3 | PSV |
| 2025 5 April | | Eredivisie | Twente | 1 - 1 | Fortuna Sittard |
| 2025 16 March | | Eredivisie | Twente | 2 - 6 | Feyenoord |
| 2025 9 March | | Eredivisie | Twente | 1 - 0 | Almere City |
| 2025 23 February | | Eredivisie | Twente | 2 - 0 | NEC |
Last 5 PSV Eindhoven Away Matches
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| 2025 24 April | | Eredivisie | Twente | 1 - 3 | PSV |
| 2025 5 April | | Eredivisie | Groningen | 1 - 3 | PSV |
| 2025 15 March | | Eredivisie | RKC Waalwijk | 0 - 3 | PSV |
| 2025 12 March | | UEFA Champions League | Arsenal | 2 - 2 | PSV |
| 2025 1 March | | Eredivisie | Go Ahead Eagles | 3 - 2 | PSV |
Last 5 FC Twente Away Matches
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| 2025 4 May | | Eredivisie | Sparta Rotterdam | 0 - 2 | Twente |
| 2025 13 April | | Eredivisie | PEC Zwolle | 1 - 1 | Twente |
| 2025 30 March | | Eredivisie | Heracles | 2 - 1 | Twente |
| 2025 1 March | | Eredivisie | Groningen | 1 - 1 | Twente |
| 2025 20 February | | UEFA Europa League | Bodo / Glimt | 3 - 2 | Twente |