This page lists the head-to-head record of Sampdoria vs Palermo including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Palermo | Sampdoria | Draws |
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| Total Matches | 30 | 11 | 9 | 10 |
| At Stadio Renzo Barbera | 15 | 5 | 6 | 4 |
| At Luigi Ferraris | 15 | 6 | 3 | 6 |
| Cup Matches | 2 | 0 | 2 | 0 |
| Serie B Matches | 6 | 2 | 2 | 2 |
| Serie A Matches | 22 | 9 | 5 | 8 |
| Total Goals Scored | 67 | 37 | 30 | |
Last 50 Palermo vs Sampdoria Matches
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| 2024 6 April | | Serie B | Palermo | 2 - 2 | Sampdoria |
| 2023 4 November | | Serie B | Sampdoria | 1 - 0 | Palermo |
| 2017 26 February | | Serie A | Palermo | 1 - 1 | Sampdoria |
| 2016 2 October | | Serie A | Sampdoria | 1 - 1 | Palermo |
| 2016 1 May | | Serie A | Palermo | 2 - 0 | Sampdoria |
| 2015 20 December | | Serie A | Sampdoria | 2 - 0 | Palermo |
| 2015 25 January | | Serie A | Sampdoria | 1 - 1 | Palermo |
| 2014 31 August | | Serie A | Palermo | 1 - 1 | Sampdoria |
| 2013 7 April | | Serie A | Sampdoria | 1 - 3 | Palermo |
| 2012 11 November | | Serie A | Palermo | 2 - 0 | Sampdoria |
| 2011 15 May | | Serie A | Sampdoria | 1 - 2 | Palermo |
| 2011 6 January | | Serie A | Palermo | 3 - 0 | Sampdoria |
| 2010 9 May | | Serie A | Palermo | 1 - 1 | Sampdoria |
| 2010 6 January | | Serie A | Sampdoria | 1 - 1 | Palermo |
| 2009 31 May | | Serie A | Palermo | 2 - 2 | Sampdoria |
| 2009 18 January | | Serie A | Sampdoria | 0 - 2 | Palermo |
| 2008 11 May | | Serie A | Palermo | 0 - 2 | Sampdoria |
| 2008 13 January | | Serie A | Sampdoria | 3 - 0 | Palermo |
| 2007 17 March | | Serie A | Sampdoria | 1 - 1 | Palermo |
| 2006 29 November | | Cup | Palermo | 2 - 3 | Sampdoria |
| 2006 7 November | | Cup | Sampdoria | 1 - 0 | Palermo |
| 2006 5 November | | Serie A | Palermo | 2 - 0 | Sampdoria |
| 2006 18 March | | Serie A | Sampdoria | 0 - 2 | Palermo |
| 2005 5 November | | Serie A | Palermo | 0 - 2 | Sampdoria |
| 2005 15 April | | Serie A | Sampdoria | 1 - 0 | Palermo |
| 2004 13 November | | Serie A | Palermo | 2 - 0 | Sampdoria |
| 2003 1 February | | Serie B | Sampdoria | 1 - 0 | Palermo |
| 2003 5 January | | Serie B | Palermo | 0 - 0 | Sampdoria |
| 2002 23 February | | Serie B | Palermo | 2 - 0 | Sampdoria |
| 2001 29 September | | Serie B | Sampdoria | 1 - 2 | Palermo |
Biggest Palermo Victory vs Sampdoria
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| 2011 6 January | | Serie A | Palermo | 3 - 0 | Sampdoria |
Biggest Sampdoria Victory vs Palermo
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| 2008 13 January | | Serie A | Sampdoria | 3 - 0 | Palermo |
Biggest Palermo Defeat vs Sampdoria
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| 2008 13 January | | Serie A | Sampdoria | 3 - 0 | Palermo |
Biggest Sampdoria Defeat vs Palermo
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| 2011 6 January | | Serie A | Palermo | 3 - 0 | Sampdoria |
Last 5 Palermo Home Matches
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| 2024 6 April | | Serie B | Palermo | 2 - 2 | Sampdoria |
| 2024 15 March | | Serie B | Palermo | 0 - 3 | Venezia |
| 2024 27 February | | Serie B | Palermo | 2 - 3 | Ternana |
| 2024 17 February | | Serie B | Palermo | 3 - 0 | Como |
| 2024 2 February | | Serie B | Palermo | 3 - 0 | Bari 1908 |
Last 5 Sampdoria Home Matches
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| 2024 13 April | | Serie B | Sampdoria | 0 - 1 | Sudtirol |
| 2024 1 April | | Serie B | Sampdoria | 4 - 1 | Ternana |
| 2024 11 March | | Serie B | Sampdoria | 2 - 1 | Ascoli Picchio |
| 2024 27 February | | Serie B | Sampdoria | 1 - 2 | Cremonese |
| 2024 17 February | | Serie B | Sampdoria | 1 - 1 | Brescia |
Last 5 Palermo Away Matches
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| 2024 13 April | | Serie B | Nuova Cosenza | 1 - 1 | Palermo |
| 2024 1 April | | Serie B | Pisa | 4 - 3 | Palermo |
| 2024 10 March | | Serie B | Lecco | 0 - 1 | Palermo |
| 2024 2 March | | Serie B | Brescia | 4 - 2 | Palermo |
| 2024 24 February | | Serie B | Cremonese | 2 - 2 | Palermo |
Last 5 Sampdoria Away Matches
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| 2024 6 April | | Serie B | Palermo | 2 - 2 | Sampdoria |
| 2024 16 March | | Serie B | Bari 1908 | 0 - 1 | Sampdoria |
| 2024 3 March | | Serie B | FeralpiSalo | 1 - 3 | Sampdoria |
| 2024 23 February | | Serie B | Nuova Cosenza | 1 - 2 | Sampdoria |
| 2024 10 February | | Serie B | Pisa | 2 - 0 | Sampdoria |