This page lists the head-to-head record of Empoli vs Palermo including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Palermo | Empoli | Draws |
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| Total Matches | 19 | 5 | 9 | 5 |
| At Stadio Renzo Barbera | 10 | 2 | 6 | 2 |
| At Stadio Carlo Castellani | 9 | 3 | 3 | 3 |
| Serie B Matches | 7 | 2 | 3 | 2 |
| Serie A Matches | 12 | 3 | 6 | 3 |
| Total Goals Scored | 50 | 20 | 30 | |
Last 50 Palermo vs Empoli Matches
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| 2025 7 December | | Serie B | Empoli | 1 - 3 | Palermo |
| 2018 2 February | | Serie B | Empoli | 4 - 0 | Palermo |
| 2017 9 September | | Serie B | Palermo | 3 - 3 | Empoli |
| 2017 28 May | | Serie A | Palermo | 2 - 1 | Empoli |
| 2017 7 January | | Serie A | Empoli | 1 - 0 | Palermo |
| 2016 19 March | | Serie A | Empoli | 0 - 0 | Palermo |
| 2015 2 November | | Serie A | Palermo | 0 - 1 | Empoli |
| 2015 1 March | | Serie A | Palermo | 0 - 0 | Empoli |
| 2014 5 October | | Serie A | Empoli | 3 - 0 | Palermo |
| 2014 3 February | | Serie B | Empoli | 1 - 1 | Palermo |
| 2013 31 August | | Serie B | Palermo | 1 - 2 | Empoli |
| 2008 27 February | | Serie A | Palermo | 2 - 0 | Empoli |
| 2007 30 September | | Serie A | Empoli | 3 - 1 | Palermo |
| 2007 11 February | | Serie A | Palermo | 0 - 1 | Empoli |
| 2006 24 September | | Serie A | Empoli | 2 - 0 | Palermo |
| 2006 11 February | | Serie A | Empoli | 0 - 1 | Palermo |
| 2005 1 October | | Serie A | Palermo | 2 - 2 | Empoli |
| 2002 12 January | | Serie B | Palermo | 1 - 0 | Empoli |
| 2001 25 August | | Serie B | Empoli | 5 - 3 | Palermo |
Biggest Palermo Victory vs Empoli
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| 2025 7 December | | Serie B | Empoli | 1 - 3 | Palermo |
Biggest Empoli Victory vs Palermo
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| 2018 2 February | | Serie B | Empoli | 4 - 0 | Palermo |
Biggest Palermo Defeat vs Empoli
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| 2018 2 February | | Serie B | Empoli | 4 - 0 | Palermo |
Biggest Empoli Defeat vs Palermo
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| 2025 7 December | | Serie B | Empoli | 1 - 3 | Palermo |
Last 5 Palermo Home Matches
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| 2026 18 January | | Serie B | Palermo | 1 - 0 | Spezia |
| 2025 27 December | | Serie B | Palermo | 1 - 0 | Calcio Padova |
| 2025 12 December | | Serie B | Palermo | 1 - 0 | Sampdoria |
| 2025 29 November | | Serie B | Palermo | 5 - 0 | Carrarese |
| 2025 1 November | | Serie B | Palermo | 5 - 0 | Pescara |
Last 5 Empoli Home Matches
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| 2026 17 January | | Serie B | Empoli | 0 - 1 | Sudtirol |
| 2025 27 December | | Serie B | Empoli | 1 - 1 | Frosinone |
| 2025 7 December | | Serie B | Empoli | 1 - 3 | Palermo |
| 2025 29 November | | Serie B | Empoli | 5 - 0 | Bari 1908 |
| 2025 8 November | | Serie B | Empoli | 1 - 0 | Catanzaro |
Last 5 Palermo Away Matches
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| 2026 24 January | | Serie B | Modena | 0 - 0 | Palermo |
| 2026 11 January | | Serie B | Mantova | 1 - 1 | Palermo |
| 2025 20 December | | Serie B | Avellino | 2 - 2 | Palermo |
| 2025 7 December | | Serie B | Empoli | 1 - 3 | Palermo |
| 2025 22 November | | Serie B | Virtus Entella | 1 - 1 | Palermo |
Last 5 Empoli Away Matches
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| 2026 23 January | | Serie B | Carrarese | 3 - 0 | Empoli |
| 2026 10 January | | Serie B | Cesena | 0 - 1 | Empoli |
| 2025 21 December | | Serie B | Mantova | 0 - 1 | Empoli |
| 2025 13 December | | Serie B | Juve Stabia | 2 - 0 | Empoli |
| 2025 22 November | | Serie B | Avellino | 0 - 3 | Empoli |