This page lists the head-to-head record of Sampdoria vs Napoli including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Napoli | Sampdoria | Draws |
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| Total Matches | 46 | 29 | 8 | 9 |
| At Stadio San Paolo | 23 | 13 | 6 | 4 |
| At Luigi Ferraris | 23 | 16 | 2 | 5 |
| Serie B Matches | 6 | 3 | 1 | 2 |
| Serie A Matches | 40 | 26 | 7 | 7 |
| Total Goals Scored | 131 | 84 | 47 | |
Last 50 Napoli vs Sampdoria Matches
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| 2023 4 June | | Serie A | Napoli | 2 - 0 | Sampdoria |
| 2023 8 January | | Serie A | Sampdoria | 0 - 2 | Napoli |
| 2022 9 January | | Serie A | Napoli | 1 - 0 | Sampdoria |
| 2021 23 September | | Serie A | Sampdoria | 0 - 4 | Napoli |
| 2021 11 April | | Serie A | Sampdoria | 0 - 2 | Napoli |
| 2020 13 December | | Serie A | Napoli | 2 - 1 | Sampdoria |
| 2020 3 February | | Serie A | Sampdoria | 2 - 4 | Napoli |
| 2019 14 September | | Serie A | Napoli | 2 - 0 | Sampdoria |
| 2019 2 February | | Serie A | Napoli | 3 - 0 | Sampdoria |
| 2018 2 September | | Serie A | Sampdoria | 3 - 0 | Napoli |
| 2018 13 May | | Serie A | Sampdoria | 0 - 2 | Napoli |
| 2017 23 December | | Serie A | Napoli | 3 - 2 | Sampdoria |
| 2017 28 May | | Serie A | Sampdoria | 2 - 4 | Napoli |
| 2017 7 January | | Serie A | Napoli | 2 - 1 | Sampdoria |
| 2016 24 January | | Serie A | Sampdoria | 2 - 4 | Napoli |
| 2015 30 August | | Serie A | Napoli | 2 - 2 | Sampdoria |
| 2015 26 April | | Serie A | Napoli | 4 - 2 | Sampdoria |
| 2014 1 December | | Serie A | Sampdoria | 1 - 1 | Napoli |
| 2014 11 May | | Serie A | Sampdoria | 2 - 5 | Napoli |
| 2014 6 January | | Serie A | Napoli | 2 - 0 | Sampdoria |
| 2013 17 February | | Serie A | Napoli | 0 - 0 | Sampdoria |
| 2012 30 September | | Serie A | Sampdoria | 0 - 1 | Napoli |
| 2011 30 January | | Serie A | Napoli | 4 - 0 | Sampdoria |
| 2010 19 September | | Serie A | Sampdoria | 1 - 2 | Napoli |
| 2010 16 May | | Serie A | Sampdoria | 1 - 0 | Napoli |
| 2010 10 January | | Serie A | Napoli | 1 - 0 | Sampdoria |
| 2009 5 April | | Serie A | Sampdoria | 2 - 2 | Napoli |
| 2008 9 November | | Serie A | Napoli | 2 - 0 | Sampdoria |
| 2008 10 February | | Serie A | Sampdoria | 2 - 0 | Napoli |
| 2007 16 September | | Serie A | Napoli | 2 - 0 | Sampdoria |
| 2003 9 March | | Serie B | Sampdoria | 2 - 0 | Napoli |
| 2002 4 October | | Serie B | Napoli | 1 - 1 | Sampdoria |
| 2002 29 March | | Serie B | Sampdoria | 0 - 2 | Napoli |
| 2001 27 October | | Serie B | Napoli | 1 - 1 | Sampdoria |
| 2000 21 April | | Serie B | Sampdoria | 0 - 2 | Napoli |
| 1999 21 November | | Serie B | Napoli | 1 - 0 | Sampdoria |
| 1998 18 April | | Serie A | Napoli | 0 - 2 | Sampdoria |
| 1997 20 December | | Serie A | Sampdoria | 6 - 3 | Napoli |
| 1997 22 February | | Serie A | Napoli | 1 - 1 | Sampdoria |
| 1996 28 September | | Serie A | Sampdoria | 0 - 1 | Napoli |
| 1996 27 April | | Serie A | Napoli | 1 - 0 | Sampdoria |
| 1995 22 December | | Serie A | Sampdoria | 2 - 2 | Napoli |
| 1995 1 April | | Serie A | Napoli | 2 - 0 | Sampdoria |
| 1994 29 October | | Serie A | Sampdoria | 0 - 0 | Napoli |
| 1994 8 January | | Serie A | Sampdoria | 4 - 1 | Napoli |
| 1993 28 August | | Serie A | Napoli | 1 - 2 | Sampdoria |
Biggest Napoli Victory vs Sampdoria
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| 2021 23 September | | Serie A | Sampdoria | 0 - 4 | Napoli |
Biggest Sampdoria Victory vs Napoli
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| 2018 2 September | | Serie A | Sampdoria | 3 - 0 | Napoli |
Biggest Napoli Defeat vs Sampdoria
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| 2018 2 September | | Serie A | Sampdoria | 3 - 0 | Napoli |
Biggest Sampdoria Defeat vs Napoli
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| 2021 23 September | | Serie A | Sampdoria | 0 - 4 | Napoli |
Last 5 Napoli Home Matches
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| 2025 25 October | | Serie A | Napoli | 3 - 1 | Internazionale |
| 2025 5 October | | Serie A | Napoli | 2 - 1 | Genoa |
| 2025 1 October | | UEFA Champions League | Napoli | 2 - 1 | Sporting Lisbon |
| 2025 22 September | | Serie A | Napoli | 3 - 2 | Pisa |
| 2025 30 August | | Serie A | Napoli | 1 - 0 | Cagliari |
Last 5 Sampdoria Home Matches
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| 2025 25 October | | Serie B | Sampdoria | 1 - 1 | Frosinone |
| 2025 5 October | | Serie B | Sampdoria | 4 - 1 | Pescara |
| 2025 1 October | | Serie B | Sampdoria | 0 - 0 | Catanzaro |
| 2025 13 September | | Serie B | Sampdoria | 1 - 2 | Cesena |
| 2025 25 August | | Serie B | Sampdoria | 0 - 2 | Modena |
Last 5 Napoli Away Matches
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| 2025 21 October | | UEFA Champions League | PSV | 6 - 2 | Napoli |
| 2025 18 October | | Serie A | Torino | 1 - 0 | Napoli |
| 2025 28 September | | Serie A | Milan | 2 - 1 | Napoli |
| 2025 18 September | | UEFA Champions League | Manchester City | 2 - 0 | Napoli |
| 2025 13 September | | Serie A | Fiorentina | 1 - 3 | Napoli |
Last 5 Sampdoria Away Matches
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| 2025 17 October | | Serie B | Virtus Entella | 3 - 1 | Sampdoria |
| 2025 27 September | | Serie B | Bari 1908 | 1 - 1 | Sampdoria |
| 2025 20 September | | Serie B | Monza | 1 - 0 | Sampdoria |
| 2025 31 August | | Serie B | Sudtirol | 3 - 1 | Sampdoria |
| 2025 18 August | | Cup | Spezia | 1 - 1 | Sampdoria |