This page lists the head-to-head record of Empoli vs Napoli including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Napoli | Empoli | Draws |
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| Total Matches | 16 | 6 | 6 | 4 |
| At Stadio San Paolo | 8 | 1 | 5 | 2 |
| At Stadio Carlo Castellani | 8 | 5 | 1 | 2 |
| Serie B Matches | 4 | 1 | 2 | 1 |
| Serie A Matches | 12 | 5 | 4 | 3 |
| Total Goals Scored | 55 | 27 | 28 | |
Last 50 Napoli vs Empoli Matches
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| 2019 3 April | | Serie A | Empoli | 2 - 1 | Napoli |
| 2018 2 November | | Serie A | Napoli | 5 - 1 | Empoli |
| 2017 19 March | | Serie A | Empoli | 2 - 3 | Napoli |
| 2016 26 October | | Serie A | Napoli | 2 - 0 | Empoli |
| 2016 31 January | | Serie A | Napoli | 5 - 1 | Empoli |
| 2015 13 September | | Serie A | Empoli | 2 - 2 | Napoli |
| 2015 30 April | | Serie A | Empoli | 4 - 2 | Napoli |
| 2014 7 December | | Serie A | Napoli | 2 - 2 | Empoli |
| 2008 17 February | | Serie A | Napoli | 1 - 3 | Empoli |
| 2007 23 September | | Serie A | Empoli | 0 - 0 | Napoli |
| 2002 17 February | | Serie B | Napoli | 0 - 0 | Empoli |
| 2001 22 September | | Serie B | Empoli | 1 - 0 | Napoli |
| 2000 7 May | | Serie B | Empoli | 4 - 1 | Napoli |
| 1999 4 December | | Serie B | Napoli | 1 - 0 | Empoli |
| 1998 7 February | | Serie A | Empoli | 5 - 0 | Napoli |
| 1997 13 September | | Serie A | Napoli | 2 - 1 | Empoli |
Biggest Napoli Victory vs Empoli
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| 2018 2 November | | Serie A | Napoli | 5 - 1 | Empoli |
Biggest Empoli Victory vs Napoli
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| 1998 7 February | | Serie A | Empoli | 5 - 0 | Napoli |
Biggest Napoli Defeat vs Empoli
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| 1998 7 February | | Serie A | Empoli | 5 - 0 | Napoli |
Biggest Empoli Defeat vs Napoli
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| 2018 2 November | | Serie A | Napoli | 5 - 1 | Empoli |
Last 5 Napoli Home Matches
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| 2019 29 September | | Serie A | Napoli | 2 - 1 | Brescia |
| 2019 25 September | | Serie A | Napoli | 0 - 1 | Cagliari |
| 2019 17 September | | UEFA Champions League | Napoli | 2 - 0 | Liverpool |
| 2019 14 September | | Serie A | Napoli | 2 - 0 | Sampdoria |
| 2019 19 May | | Serie A | Napoli | 4 - 1 | Internazionale |
Last 5 Empoli Home Matches
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| 2019 28 September | | Serie B | Empoli | 3 - 0 | Perugia |
| 2019 21 September | | Serie B | Empoli | 1 - 0 | Cittadella |
| 2019 25 August | | Serie B | Empoli | 2 - 1 | Juve Stabia |
| 2019 18 August | | Cup | Empoli | 1 - 1 | Pescara |
| 2019 11 August | | Cup | Empoli | 2 - 1 | Reggio Calabria |
Last 5 Napoli Away Matches
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| 2019 6 October | | Serie A | Torino | 0 - 0 | Napoli |
| 2019 2 October | | UEFA Champions League | Genk | 0 - 0 | Napoli |
| 2019 22 September | | Serie A | Lecce | 1 - 4 | Napoli |
| 2019 31 August | | Serie A | Juventus | 4 - 3 | Napoli |
| 2019 24 August | | Serie A | Fiorentina | 3 - 4 | Napoli |
Last 5 Empoli Away Matches
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| 2019 5 October | | Serie B | Pordenone | 2 - 0 | Empoli |
| 2019 24 September | | Serie B | Pisa | 2 - 3 | Empoli |
| 2019 15 September | | Serie B | Crotone | 0 - 0 | Empoli |
| 2019 30 August | | Serie B | Chievo | 1 - 1 | Empoli |
| 2019 26 May | | Serie A | Internazionale | 2 - 1 | Empoli |