This page lists the head-to-head record of Istres vs Lyon including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Lyon | Istres | Draws |
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| Total Matches | 2 | 1 | 0 | 1 |
| At Parc OL | 1 | 0 | 0 | 1 |
| At Stade Parsemain | 1 | 1 | 0 | 0 |
| Ligue 1 Matches | 2 | 1 | 0 | 1 |
| Total Goals Scored | 3 | 2 | 1 | |
Last 50 Lyon vs Istres Matches
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
| 2004 22 October | | Ligue 1 | Istres | 0 - 0 | Olympique Lyonnais |
Biggest Lyon Victory vs Istres
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Biggest Istres Defeat vs Lyon
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Last 5 Lyon Home Matches
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| 2025 5 October | | Ligue 1 | Olympique Lyonnais | 1 - 2 | Toulouse |
| 2025 2 October | | UEFA Europa League | Olympique Lyonnais | 2 - 0 | Salzburg |
| 2025 19 September | | Ligue 1 | Olympique Lyonnais | 1 - 0 | Angers SCO |
| 2025 31 August | | Ligue 1 | Olympique Lyonnais | 1 - 0 | Olympique Marseille |
| 2025 23 August | | Ligue 1 | Olympique Lyonnais | 3 - 0 | Metz |
Last 5 Istres Home Matches
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| 2025 19 September | | CFA | Istres | 1 - 1 | Andrezieux ASF |
| 2025 5 September | | CFA | Istres | 0 - 0 | Hyeres FC |
| 2025 23 August | | CFA | Istres | 4 - 1 | Rousset-Ste Victoire |
| 2025 17 May | | CFA | Istres | 4 - 2 | Jura Sud Foot |
| 2025 2 May | | CFA | Istres | 0 - 0 | Rumilly Vallieres |
Last 5 Lyon Away Matches
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| 2025 28 September | | Ligue 1 | Lille | 0 - 1 | Olympique Lyonnais |
| 2025 25 September | | UEFA Europa League | Utrecht | 0 - 1 | Olympique Lyonnais |
| 2025 14 September | | Ligue 1 | Stade Rennes | 3 - 1 | Olympique Lyonnais |
| 2025 16 August | | Ligue 1 | Lens | 0 - 1 | Olympique Lyonnais |
| 2025 10 May | | Ligue 1 | Monaco | 2 - 0 | Olympique Lyonnais |
Last 5 Istres Away Matches
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| 2025 3 October | | CFA | Saint-Priest | 1 - 2 | Istres |
| 2025 12 September | | CFA | Cannes | 2 - 2 | Istres |
| 2025 30 August | | CFA | St Maur Lusitanos | 1 - 0 | Istres |
| 2025 16 August | | CFA | Monts d'Or Azergues | 1 - 0 | Istres |
| 2025 10 May | | CFA | Le Puy Foot | 0 - 1 | Istres |