This page lists the head-to-head record of Istres vs Lyon including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Lyon | Istres | Draws |
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| Total Matches | 2 | 1 | 0 | 1 |
| At Parc OL | 1 | 0 | 0 | 1 |
| At Stade Parsemain | 1 | 1 | 0 | 0 |
| Ligue 1 Matches | 2 | 1 | 0 | 1 |
| Total Goals Scored | 3 | 2 | 1 | |
Last 50 Lyon vs Istres Matches
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
| 2004 22 October | | Ligue 1 | Istres | 0 - 0 | Olympique Lyonnais |
Biggest Lyon Victory vs Istres
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Biggest Istres Defeat vs Lyon
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Last 5 Lyon Home Matches
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| 2024 14 April | | Ligue 1 | Olympique Lyonnais | 4 - 3 | Brest |
| 2024 2 April | | Cup | Olympique Lyonnais | 3 - 0 | Valenciennes |
| 2024 30 March | | Ligue 1 | Olympique Lyonnais | 1 - 1 | Reims |
| 2024 3 March | | Ligue 1 | Olympique Lyonnais | 0 - 3 | Lens |
| 2024 27 February | | Cup | Olympique Lyonnais | 0 - 0 | Strasbourg |
Last 5 Istres Home Matches
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| 2024 13 April | | CFA 2 | Istres | 0 - 2 | Cagnes-Le Cros |
| 2024 23 March | | CFA 2 | Istres | 0 - 1 | Agde |
| 2024 9 March | | CFA 2 | Istres | 1 - 2 | Montpellier HSC II |
| 2024 17 February | | CFA 2 | Istres | 1 - 0 | Cannet Rocheville |
| 2024 12 January | | CFA 2 | Istres | 1 - 3 | Olympique Marseille II |
Last 5 Lyon Away Matches
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| 2024 21 April | | Ligue 1 | Paris St Germain | 4 - 1 | Olympique Lyonnais |
| 2024 7 April | | Ligue 1 | Nantes | 1 - 3 | Olympique Lyonnais |
| 2024 15 March | | Ligue 1 | Toulouse | 2 - 3 | Olympique Lyonnais |
| 2024 9 March | | Ligue 1 | Lorient | 0 - 2 | Olympique Lyonnais |
| 2024 23 February | | Ligue 1 | Metz | 1 - 2 | Olympique Lyonnais |
Last 5 Istres Away Matches
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| 2024 21 April | | CFA 2 | St Clement Montferrier | 0 - 2 | Istres |
| 2024 6 April | | CFA 2 | Corte | 1 - 1 | Istres |
| 2024 16 March | | CFA 2 | Fos | 1 - 3 | Istres |
| 2024 24 February | | CFA 2 | Stade Beaucairois | 0 - 1 | Istres |
| 2024 3 February | | CFA 2 | Gallia Lucciana | 0 - 2 | Istres |