This page lists the head-to-head record of Istres vs Lyon including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Lyon | Istres | Draws |
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| Total Matches | 2 | 1 | 0 | 1 |
| At Parc OL | 1 | 0 | 0 | 1 |
| At Stade Parsemain | 1 | 1 | 0 | 0 |
| Ligue 1 Matches | 2 | 1 | 0 | 1 |
| Total Goals Scored | 3 | 2 | 1 | |
Last 50 Lyon vs Istres Matches
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
| 2004 22 October | | Ligue 1 | Istres | 0 - 0 | Olympique Lyonnais |
Biggest Lyon Victory vs Istres
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Biggest Istres Defeat vs Lyon
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Last 5 Lyon Home Matches
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| 2025 9 February | | Ligue 1 | Olympique Lyonnais | 4 - 0 | Reims |
| 2025 30 January | | UEFA Europa League | Olympique Lyonnais | 1 - 1 | Ludogorets |
| 2025 18 January | | Ligue 1 | Olympique Lyonnais | 0 - 0 | Toulouse |
| 2025 4 January | | Ligue 1 | Olympique Lyonnais | 1 - 0 | Montpellier |
| 2024 12 December | | UEFA Europa League | Olympique Lyonnais | 3 - 2 | Eintracht Frankfurt |
Last 5 Istres Home Matches
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| 2025 14 February | | CFA | Istres | 1 - 2 | Hyeres FC |
| 2025 24 January | | CFA | Istres | 0 - 2 | Saint-Priest |
| 2025 10 January | | CFA | Istres | 1 - 4 | Le Puy Foot |
| 2024 13 December | | CFA | Istres | 0 - 0 | Andrezieux ASF |
| 2024 30 November | | Cup | Istres | 0 - 4 | Grenoble Foot 38 |
Last 5 Lyon Away Matches
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| 2025 16 February | | Ligue 1 | Montpellier | 1 - 4 | Olympique Lyonnais |
| 2025 2 February | | Ligue 1 | Olympique Marseille | 3 - 2 | Olympique Lyonnais |
| 2025 26 January | | Ligue 1 | Nantes | 1 - 1 | Olympique Lyonnais |
| 2025 23 January | | UEFA Europa League | Fenerbahce | 0 - 0 | Olympique Lyonnais |
| 2025 15 January | | Cup | Bourgoin-Jallieu | 2 - 2 | Olympique Lyonnais |
Last 5 Istres Away Matches
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| 2025 8 February | | CFA | Anglet Genets | 2 - 4 | Istres |
| 2025 18 January | | CFA | Marignane Gignac CB | 2 - 7 | Istres |
| 2024 21 December | | CFA | Rumilly Vallieres | 1 - 1 | Istres |
| 2024 7 December | | CFA | Cannes | 4 - 1 | Istres |
| 2024 9 November | | CFA | Bergerac Perigord FC | 3 - 0 | Istres |