This page lists the head-to-head record of Sampdoria vs Lazio including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Lazio | Sampdoria | Draws |
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| Total Matches | 51 | 30 | 10 | 11 |
| At Stadio Olimpico | 25 | 12 | 9 | 4 |
| At Luigi Ferraris | 26 | 18 | 1 | 7 |
| Cup Matches | 1 | 0 | 0 | 1 |
| Serie A Matches | 50 | 30 | 10 | 10 |
| Total Goals Scored | 147 | 94 | 53 | |
Last 50 Lazio vs Sampdoria Matches
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| 2023 27 February | | Serie A | Lazio | 1 - 0 | Sampdoria |
| 2022 31 August | | Serie A | Sampdoria | 1 - 1 | Lazio |
| 2022 7 May | | Serie A | Lazio | 2 - 0 | Sampdoria |
| 2021 5 December | | Serie A | Sampdoria | 1 - 3 | Lazio |
| 2021 20 February | | Serie A | Lazio | 1 - 0 | Sampdoria |
| 2020 17 October | | Serie A | Sampdoria | 3 - 0 | Lazio |
| 2020 18 January | | Serie A | Lazio | 5 - 1 | Sampdoria |
| 2019 25 August | | Serie A | Sampdoria | 0 - 3 | Lazio |
| 2019 28 April | | Serie A | Sampdoria | 1 - 2 | Lazio |
| 2018 8 December | | Serie A | Lazio | 2 - 2 | Sampdoria |
| 2018 22 April | | Serie A | Lazio | 4 - 0 | Sampdoria |
| 2017 3 December | | Serie A | Sampdoria | 1 - 2 | Lazio |
| 2017 7 May | | Serie A | Lazio | 7 - 3 | Sampdoria |
| 2016 10 December | | Serie A | Sampdoria | 1 - 2 | Lazio |
| 2016 24 April | | Serie A | Sampdoria | 2 - 1 | Lazio |
| 2015 14 December | | Serie A | Lazio | 1 - 1 | Sampdoria |
| 2015 16 May | | Serie A | Sampdoria | 0 - 1 | Lazio |
| 2015 5 January | | Serie A | Lazio | 3 - 0 | Sampdoria |
| 2014 6 April | | Serie A | Lazio | 2 - 0 | Sampdoria |
| 2013 24 November | | Serie A | Sampdoria | 1 - 1 | Lazio |
| 2013 12 May | | Serie A | Lazio | 2 - 0 | Sampdoria |
| 2012 22 December | | Serie A | Sampdoria | 0 - 1 | Lazio |
| 2011 16 January | | Serie A | Lazio | 1 - 0 | Sampdoria |
| 2010 29 August | | Serie A | Sampdoria | 2 - 0 | Lazio |
| 2010 7 March | | Serie A | Sampdoria | 2 - 1 | Lazio |
| 2009 18 October | | Serie A | Lazio | 1 - 1 | Sampdoria |
| 2009 13 May | | Cup | Lazio | 1 - 1 | Sampdoria |
| 2009 28 January | | Serie A | Sampdoria | 3 - 1 | Lazio |
| 2008 14 September | | Serie A | Lazio | 2 - 0 | Sampdoria |
| 2008 3 February | | Serie A | Lazio | 2 - 1 | Sampdoria |
| 2007 2 September | | Serie A | Sampdoria | 0 - 0 | Lazio |
| 2007 4 March | | Serie A | Lazio | 1 - 0 | Sampdoria |
| 2006 25 October | | Serie A | Sampdoria | 2 - 0 | Lazio |
| 2006 25 March | | Serie A | Lazio | 2 - 0 | Sampdoria |
| 2005 19 November | | Serie A | Sampdoria | 2 - 0 | Lazio |
| 2005 22 January | | Serie A | Lazio | 1 - 2 | Sampdoria |
| 2004 11 September | | Serie A | Sampdoria | 0 - 1 | Lazio |
| 2004 31 January | | Serie A | Lazio | 1 - 1 | Sampdoria |
| 2003 12 September | | Serie A | Sampdoria | 1 - 2 | Lazio |
| 1999 24 April | | Serie A | Sampdoria | 0 - 1 | Lazio |
| 1998 12 December | | Serie A | Lazio | 5 - 2 | Sampdoria |
| 1998 13 March | | Serie A | Sampdoria | 0 - 4 | Lazio |
| 1997 8 November | | Serie A | Lazio | 3 - 0 | Sampdoria |
| 1997 12 April | | Serie A | Sampdoria | 1 - 0 | Lazio |
| 1996 23 November | | Serie A | Lazio | 1 - 1 | Sampdoria |
| 1996 20 April | | Serie A | Sampdoria | 3 - 3 | Lazio |
| 1995 16 December | | Serie A | Lazio | 6 - 3 | Sampdoria |
| 1995 20 May | | Serie A | Lazio | 1 - 0 | Sampdoria |
| 1995 7 January | | Serie A | Sampdoria | 3 - 1 | Lazio |
| 1994 30 April | | Serie A | Sampdoria | 3 - 4 | Lazio |
Biggest Lazio Victory vs Sampdoria
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| 1998 13 March | | Serie A | Sampdoria | 0 - 4 | Lazio |
Biggest Sampdoria Victory vs Lazio
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| 2020 17 October | | Serie A | Sampdoria | 3 - 0 | Lazio |
Biggest Lazio Defeat vs Sampdoria
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| 2020 17 October | | Serie A | Sampdoria | 3 - 0 | Lazio |
Biggest Sampdoria Defeat vs Lazio
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| 1998 13 March | | Serie A | Sampdoria | 0 - 4 | Lazio |
Last 5 Lazio Home Matches
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| 2024 7 November | | UEFA Europa League | Lazio | 2 - 1 | Porto |
| 2024 4 November | | Serie A | Lazio | 2 - 1 | Cagliari |
| 2024 27 October | | Serie A | Lazio | 3 - 0 | Genoa |
| 2024 6 October | | Serie A | Lazio | 2 - 1 | Empoli |
| 2024 3 October | | UEFA Europa League | Lazio | 4 - 1 | Nice |
Last 5 Sampdoria Home Matches
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| 2024 3 November | | Serie B | Sampdoria | 0 - 1 | Brescia |
| 2024 27 October | | Serie B | Sampdoria | 1 - 0 | Mantova |
| 2024 4 October | | Serie B | Sampdoria | 1 - 2 | Juve Stabia |
| 2024 21 September | | Serie B | Sampdoria | 1 - 0 | Sudtirol |
| 2024 31 August | | Serie B | Sampdoria | 0 - 0 | Bari 1908 |
Last 5 Lazio Away Matches
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| 2024 10 November | | Serie A | Monza | 0 - 1 | Lazio |
| 2024 31 October | | Serie A | Como | 1 - 5 | Lazio |
| 2024 24 October | | UEFA Europa League | Twente | 0 - 2 | Lazio |
| 2024 19 October | | Serie A | Juventus | 1 - 0 | Lazio |
| 2024 29 September | | Serie A | Torino | 2 - 3 | Lazio |
Last 5 Sampdoria Away Matches
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| 2024 9 November | | Serie B | Pisa | 3 - 0 | Sampdoria |
| 2024 30 October | | Serie B | Cittadella | 0 - 0 | Sampdoria |
| 2024 20 October | | Serie B | Cesena | 3 - 5 | Sampdoria |
| 2024 29 September | | Serie B | Modena | 1 - 3 | Sampdoria |
| 2024 25 September | | Cup | Genoa | 1 - 1 | Sampdoria |