This page lists the head-to-head record of Palermo vs Lazio including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Lazio | Palermo | Draws |
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| Total Matches | 25 | 12 | 7 | 6 |
| At Stadio Olimpico | 12 | 5 | 4 | 3 |
| At Stadio Renzo Barbera | 13 | 7 | 3 | 3 |
| Cup Matches | 1 | 1 | 0 | 0 |
| Serie A Matches | 24 | 11 | 7 | 6 |
| Total Goals Scored | 81 | 47 | 34 | |
Last 50 Lazio vs Palermo Matches
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| 2017 23 April | | Serie A | Lazio | 6 - 2 | Palermo |
| 2016 27 November | | Serie A | Palermo | 0 - 1 | Lazio |
| 2016 10 April | | Serie A | Palermo | 0 - 3 | Lazio |
| 2015 22 November | | Serie A | Lazio | 1 - 1 | Palermo |
| 2015 22 February | | Serie A | Lazio | 2 - 1 | Palermo |
| 2014 29 September | | Serie A | Palermo | 0 - 4 | Lazio |
| 2013 19 January | | Serie A | Palermo | 2 - 2 | Lazio |
| 2012 2 September | | Serie A | Lazio | 3 - 0 | Palermo |
| 2012 19 February | | Serie A | Palermo | 5 - 1 | Lazio |
| 2011 25 September | | Serie A | Lazio | 0 - 0 | Palermo |
| 2011 6 March | | Serie A | Lazio | 2 - 0 | Palermo |
| 2010 31 October | | Serie A | Palermo | 0 - 1 | Lazio |
| 2010 21 February | | Serie A | Palermo | 3 - 1 | Lazio |
| 2010 14 January | | Cup | Lazio | 2 - 0 | Palermo |
| 2009 27 September | | Serie A | Lazio | 1 - 1 | Palermo |
| 2009 17 May | | Serie A | Palermo | 2 - 0 | Lazio |
| 2008 20 December | | Serie A | Lazio | 1 - 0 | Palermo |
| 2008 4 May | | Serie A | Lazio | 1 - 2 | Palermo |
| 2007 23 December | | Serie A | Palermo | 2 - 2 | Lazio |
| 2007 27 January | | Serie A | Palermo | 0 - 3 | Lazio |
| 2006 16 September | | Serie A | Lazio | 1 - 2 | Palermo |
| 2006 7 February | | Serie A | Palermo | 3 - 1 | Lazio |
| 2005 24 September | | Serie A | Lazio | 4 - 2 | Palermo |
| 2005 28 May | | Serie A | Palermo | 3 - 3 | Lazio |
| 2005 15 January | | Serie A | Lazio | 1 - 3 | Palermo |
Biggest Lazio Victory vs Palermo
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| 2014 29 September | | Serie A | Palermo | 0 - 4 | Lazio |
Biggest Palermo Victory vs Lazio
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| 2012 19 February | | Serie A | Palermo | 5 - 1 | Lazio |
Biggest Lazio Defeat vs Palermo
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| 2012 19 February | | Serie A | Palermo | 5 - 1 | Lazio |
Biggest Palermo Defeat vs Lazio
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| 2014 29 September | | Serie A | Palermo | 0 - 4 | Lazio |
Last 5 Lazio Home Matches
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| 2025 31 March | | Serie A | Lazio | 1 - 1 | Torino |
| 2025 13 March | | UEFA Europa League | Lazio | 1 - 1 | Viktoria Plzen |
| 2025 10 March | | Serie A | Lazio | 1 - 1 | Udinese |
| 2025 15 February | | Serie A | Lazio | 2 - 2 | Napoli |
| 2025 9 February | | Serie A | Lazio | 5 - 1 | Monza |
Last 5 Palermo Home Matches
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| 2025 14 March | | Serie B | Palermo | 2 - 3 | Cremonese |
| 2025 2 March | | Serie B | Palermo | 1 - 0 | Brescia |
| 2025 16 February | | Serie B | Palermo | 2 - 2 | Mantova |
| 2025 31 January | | Serie B | Palermo | 1 - 2 | Pisa |
| 2025 19 January | | Serie B | Palermo | 1 - 0 | Juve Stabia |
Last 5 Lazio Away Matches
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| 2025 16 March | | Serie A | Bologna | 5 - 0 | Lazio |
| 2025 6 March | | UEFA Europa League | Viktoria Plzen | 1 - 2 | Lazio |
| 2025 2 March | | Serie A | Milan | 1 - 2 | Lazio |
| 2025 25 February | | Cup | Internazionale | 2 - 0 | Lazio |
| 2025 22 February | | Serie A | Venezia | 0 - 0 | Lazio |
Last 5 Palermo Away Matches
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| 2025 30 March | | Serie B | Salernitana | 1 - 2 | Palermo |
| 2025 8 March | | Serie B | Sampdoria | 1 - 1 | Palermo |
| 2025 23 February | | Serie B | Nuova Cosenza | 0 - 3 | Palermo |
| 2025 9 February | | Serie B | Spezia | 2 - 2 | Palermo |
| 2025 26 January | | Serie B | Reggiana | 2 - 1 | Palermo |