This page lists the head-to-head record of Anderlecht vs KV Mechelen including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | KV Mechelen | Anderlecht | Draws |
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| Total Matches | 45 | 7 | 26 | 12 |
| At Argosstadion Achter de Kazerne | 22 | 1 | 14 | 7 |
| At Constant Vanden Stock Stadion | 23 | 6 | 12 | 5 |
| Pro League Matches | 43 | 6 | 26 | 11 |
| Cup Matches | 2 | 1 | 0 | 1 |
| Total Goals Scored | 145 | 44 | 101 | |
Last 50 KV Mechelen vs Anderlecht Matches
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| 2024 17 August | | Pro League | Mechelen | 1 - 3 | Anderlecht |
| 2024 1 February | | Pro League | Mechelen | 2 - 2 | Anderlecht |
| 2023 7 October | | Pro League | Anderlecht | 3 - 1 | Mechelen |
| 2023 23 April | | Pro League | Anderlecht | 2 - 3 | Mechelen |
| 2022 9 October | | Pro League | Mechelen | 1 - 3 | Anderlecht |
| 2022 23 January | | Pro League | Mechelen | 0 - 1 | Anderlecht |
| 2021 12 September | | Pro League | Anderlecht | 7 - 2 | Mechelen |
| 2021 7 March | | Pro League | Anderlecht | 1 - 1 | Mechelen |
| 2020 9 August | | Pro League | Mechelen | 2 - 2 | Anderlecht |
| 2020 15 February | | Pro League | Mechelen | 2 - 0 | Anderlecht |
| 2019 9 August | | Pro League | Anderlecht | 0 - 0 | Mechelen |
| 2018 4 February | | Pro League | Anderlecht | 2 - 2 | Mechelen |
| 2017 13 October | | Pro League | Mechelen | 3 - 4 | Anderlecht |
| 2017 4 March | | Pro League | Mechelen | 3 - 2 | Anderlecht |
| 2016 26 October | | Pro League | Anderlecht | 2 - 0 | Mechelen |
| 2016 5 February | | Pro League | Mechelen | 2 - 2 | Anderlecht |
| 2015 4 October | | Pro League | Anderlecht | 1 - 1 | Mechelen |
| 2015 15 February | | Pro League | Anderlecht | 1 - 1 | Mechelen |
| 2014 18 October | | Pro League | Mechelen | 1 - 1 | Anderlecht |
| 2014 19 January | | Pro League | Mechelen | 2 - 1 | Anderlecht |
| 2013 14 September | | Pro League | Anderlecht | 5 - 0 | Mechelen |
| 2013 9 March | | Pro League | Anderlecht | 1 - 0 | Mechelen |
| 2012 27 November | | Cup | Anderlecht | 0 - 0 | Mechelen |
| 2012 3 November | | Pro League | Mechelen | 1 - 4 | Anderlecht |
| 2011 9 December | | Pro League | Mechelen | 2 - 1 | Anderlecht |
| 2011 5 August | | Pro League | Anderlecht | 3 - 1 | Mechelen |
| 2011 30 January | | Pro League | Mechelen | 0 - 0 | Anderlecht |
| 2010 26 September | | Pro League | Anderlecht | 5 - 0 | Mechelen |
| 2010 21 February | | Pro League | Anderlecht | 2 - 0 | Mechelen |
| 2009 25 October | | Pro League | Mechelen | 0 - 2 | Anderlecht |
| 2009 13 March | | Pro League | Mechelen | 2 - 1 | Anderlecht |
| 2009 13 January | | Cup | Mechelen | 2 - 1 | Anderlecht |
| 2008 25 October | | Pro League | Anderlecht | 7 - 1 | Mechelen |
| 2008 19 January | | Pro League | Anderlecht | 1 - 0 | Mechelen |
| 2007 3 August | | Pro League | Mechelen | 0 - 1 | Anderlecht |
| 2003 24 January | | Pro League | Mechelen | 0 - 2 | Anderlecht |
| 2002 16 August | | Pro League | Anderlecht | 4 - 1 | Mechelen |
| 2001 12 May | | Pro League | Anderlecht | 1 - 0 | Mechelen |
| 2000 8 December | | Pro League | Mechelen | 0 - 2 | Anderlecht |
| 2000 31 March | | Pro League | Anderlecht | 5 - 0 | Mechelen |
| 1999 5 November | | Pro League | Mechelen | 2 - 5 | Anderlecht |
| 1997 24 May | | Pro League | Mechelen | 0 - 2 | Anderlecht |
| 1996 29 November | | Pro League | Anderlecht | 0 - 0 | Mechelen |
| 1996 17 February | | Pro League | Anderlecht | 3 - 1 | Mechelen |
| 1995 9 September | | Pro League | Mechelen | 1 - 3 | Anderlecht |
Biggest KV Mechelen Victory vs Anderlecht
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| 2020 15 February | | Pro League | Mechelen | 2 - 0 | Anderlecht |
Biggest Anderlecht Victory vs KV Mechelen
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| 2008 25 October | | Pro League | Anderlecht | 7 - 1 | Mechelen |
Biggest KV Mechelen Defeat vs Anderlecht
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| 2008 25 October | | Pro League | Anderlecht | 7 - 1 | Mechelen |
Biggest Anderlecht Defeat vs KV Mechelen
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| 2020 15 February | | Pro League | Mechelen | 2 - 0 | Anderlecht |
Last 5 KV Mechelen Home Matches
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| 2024 2 November | | Pro League | Mechelen | 1 - 1 | Union Saint-Gilloise |
| 2024 30 October | | Cup | Mechelen | 3 - 1 | RAAL La Louviere |
| 2024 20 October | | Pro League | Mechelen | 3 - 0 | Kortrijk |
| 2024 5 October | | Pro League | Mechelen | 5 - 0 | OH Leuven |
| 2024 22 September | | Pro League | Mechelen | 2 - 0 | Cercle Brugge |
Last 5 Anderlecht Home Matches
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| 2024 3 November | | Pro League | Anderlecht | 4 - 0 | Kortrijk |
| 2024 24 October | | UEFA Europa League | Anderlecht | 2 - 0 | Ludogorets |
| 2024 6 October | | Pro League | Anderlecht | 3 - 0 | Standard Liege |
| 2024 25 September | | UEFA Europa League | Anderlecht | 2 - 1 | Ferencvaros |
| 2024 21 September | | Pro League | Anderlecht | 0 - 0 | Sporting Charleroi |
Last 5 KV Mechelen Away Matches
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| 2024 8 November | | Pro League | Sint-Truiden | 2 - 1 | Mechelen |
| 2024 26 October | | Pro League | Dender | 2 - 5 | Mechelen |
| 2024 28 September | | Pro League | Genk | 2 - 1 | Mechelen |
| 2024 15 September | | Pro League | Gent | 2 - 0 | Mechelen |
| 2024 24 August | | Pro League | Antwerp | 0 - 1 | Mechelen |
Last 5 Anderlecht Away Matches
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| 2024 10 November | | Pro League | Cercle Brugge | 0 - 5 | Anderlecht |
| 2024 7 November | | UEFA Europa League | Rigas FS | 1 - 1 | Anderlecht |
| 2024 31 October | | Cup | Tubize | 0 - 4 | Anderlecht |
| 2024 27 October | | Pro League | Club Brugge | 2 - 1 | Anderlecht |
| 2024 18 October | | Pro League | Beerschot-Wilrijk | 2 - 1 | Anderlecht |