This page lists the head-to-head record of FSV Mainz vs Karlsruhe SC including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Karlsruhe SC | FSV Mainz | Draws |
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| Total Matches | 11 | 0 | 5 | 6 |
| At Wildparkstadion | 5 | 0 | 2 | 3 |
| At Opel Arena | 6 | 0 | 3 | 3 |
| Bundesliga 2 Matches | 10 | 0 | 5 | 5 |
| Cup Matches | 1 | 0 | 0 | 1 |
| Total Goals Scored | 29 | 10 | 19 | |
Last 50 Karlsruhe SC vs FSV Mainz Matches
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| 2004 20 September | | Cup | Karlsruher SC | 1 - 1 | Mainz 05 |
| 2004 14 March | | Bundesliga 2 | Karlsruher SC | 1 - 1 | Mainz 05 |
| 2003 28 September | | Bundesliga 2 | Mainz 05 | 1 - 1 | Karlsruher SC |
| 2003 10 April | | Bundesliga 2 | Karlsruher SC | 0 - 0 | Mainz 05 |
| 2002 3 November | | Bundesliga 2 | Mainz 05 | 2 - 2 | Karlsruher SC |
| 2002 5 February | | Bundesliga 2 | Karlsruher SC | 1 - 4 | Mainz 05 |
| 2001 18 August | | Bundesliga 2 | Mainz 05 | 1 - 0 | Karlsruher SC |
| 2000 25 March | | Bundesliga 2 | Mainz 05 | 2 - 2 | Karlsruher SC |
| 1999 1 October | | Bundesliga 2 | Karlsruher SC | 1 - 2 | Mainz 05 |
| 1999 25 February | | Bundesliga 2 | Karlsruher SC | 0 - 1 | Mainz 05 |
| 1998 12 August | | Bundesliga 2 | Mainz 05 | 4 - 1 | Karlsruher SC |
Biggest FSV Mainz Victory vs Karlsruhe SC
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| 2002 5 February | | Bundesliga 2 | Karlsruher SC | 1 - 4 | Mainz 05 |
Biggest Karlsruhe SC Defeat vs FSV Mainz
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| 2002 5 February | | Bundesliga 2 | Karlsruher SC | 1 - 4 | Mainz 05 |
Last 5 Karlsruhe SC Home Matches
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| 2025 1 November | | Bundesliga 2 | Karlsruher SC | 2 - 1 | Schalke 04 |
| 2025 18 October | | Bundesliga 2 | Karlsruher SC | 2 - 3 | Kaiserslautern |
| 2025 27 September | | Bundesliga 2 | Karlsruher SC | 1 - 0 | Magdeburg |
| 2025 13 September | | Bundesliga 2 | Karlsruher SC | 2 - 1 | Nurnberg |
| 2025 23 August | | Bundesliga 2 | Karlsruher SC | 2 - 0 | Eintracht Braunschweig |
Last 5 FSV Mainz Home Matches
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| 2025 6 November | | Europa Conference League | Mainz 05 | 2 - 1 | Fiorentina |
| 2025 1 November | | Bundesliga | Mainz 05 | 1 - 1 | Werder Bremen |
| 2025 29 October | | Cup | Mainz 05 | 0 - 2 | Stuttgart |
| 2025 23 October | | Europa Conference League | Mainz 05 | 1 - 0 | Zrinjski |
| 2025 18 October | | Bundesliga | Mainz 05 | 3 - 4 | Bayer Leverkusen |
Last 5 Karlsruhe SC Away Matches
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| 2025 8 November | | Bundesliga 2 | Arminia Bielefeld | 4 - 0 | Karlsruher SC |
| 2025 28 October | | Cup | Borussia M'gladbach | 3 - 1 | Karlsruher SC |
| 2025 24 October | | Bundesliga 2 | Greuther Furth | 1 - 4 | Karlsruher SC |
| 2025 4 October | | Bundesliga 2 | Dynamo Dresden | 3 - 3 | Karlsruher SC |
| 2025 21 September | | Bundesliga 2 | Holstein Kiel | 3 - 0 | Karlsruher SC |
Last 5 FSV Mainz Away Matches
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| 2025 9 November | | Bundesliga | Eintracht Frankfurt | 1 - 0 | Mainz 05 |
| 2025 26 October | | Bundesliga | Stuttgart | 2 - 1 | Mainz 05 |
| 2025 5 October | | Bundesliga | Hamburger SV | 4 - 0 | Mainz 05 |
| 2025 2 October | | Europa Conference League | Omonia Nicosia | 0 - 1 | Mainz 05 |
| 2025 20 September | | Bundesliga | Augsburg | 1 - 4 | Mainz 05 |