This page lists the head-to-head record of Lyon vs Istres including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Istres | Lyon | Draws |
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| Total Matches | 2 | 0 | 1 | 1 |
| At Stade Parsemain | 1 | 0 | 1 | 0 |
| At Parc OL | 1 | 0 | 0 | 1 |
| Ligue 1 Matches | 2 | 0 | 1 | 1 |
| Total Goals Scored | 3 | 1 | 2 | |
Last 50 Istres vs Lyon Matches
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
| 2004 22 October | | Ligue 1 | Istres | 0 - 0 | Olympique Lyonnais |
Biggest Lyon Victory vs Istres
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Biggest Istres Defeat vs Lyon
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Last 5 Istres Home Matches
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| 2025 17 May | | CFA | Istres | 4 - 2 | Jura Sud Foot |
| 2025 2 May | | CFA | Istres | 0 - 0 | Rumilly Vallieres |
| 2025 18 April | | CFA | Istres | 0 - 2 | Cannes |
| 2025 4 April | | CFA | Istres | 0 - 2 | Bergerac Perigord FC |
| 2025 22 March | | CFA | Istres | 4 - 2 | Grasse |
Last 5 Lyon Home Matches
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| 2025 17 May | | Ligue 1 | Olympique Lyonnais | 2 - 0 | Angers SCO |
| 2025 4 May | | Ligue 1 | Olympique Lyonnais | 1 - 2 | Lens |
| 2025 26 April | | Ligue 1 | Olympique Lyonnais | 4 - 1 | Stade Rennes |
| 2025 10 April | | UEFA Europa League | Olympique Lyonnais | 2 - 2 | Manchester United |
| 2025 5 April | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Lille |
Last 5 Istres Away Matches
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| 2025 10 May | | CFA | Le Puy Foot | 0 - 1 | Istres |
| 2025 25 April | | CFA | Andrezieux ASF | 3 - 1 | Istres |
| 2025 12 April | | CFA | Toulon | 3 - 1 | Istres |
| 2025 14 March | | CFA | Monts d'Or Azergues | 1 - 2 | Istres |
| 2025 21 February | | CFA | Angouleme | 1 - 0 | Istres |
Last 5 Lyon Away Matches
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| 2025 10 May | | Ligue 1 | Monaco | 2 - 0 | Olympique Lyonnais |
| 2025 20 April | | Ligue 1 | Saint-Etienne | 2 - 1 | Olympique Lyonnais |
| 2025 17 April | | UEFA Europa League | Manchester United | 2 - 2 | Olympique Lyonnais |
| 2025 13 April | | Ligue 1 | Auxerre | 1 - 3 | Olympique Lyonnais |
| 2025 28 March | | Ligue 1 | Strasbourg | 4 - 2 | Olympique Lyonnais |