This page lists the head-to-head record of Lyon vs Istres including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Istres | Lyon | Draws |
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| Total Matches | 2 | 0 | 1 | 1 |
| At Stade Parsemain | 1 | 0 | 1 | 0 |
| At Parc OL | 1 | 0 | 0 | 1 |
| Ligue 1 Matches | 2 | 0 | 1 | 1 |
| Total Goals Scored | 3 | 1 | 2 | |
Last 50 Istres vs Lyon Matches
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
| 2004 22 October | | Ligue 1 | Istres | 0 - 0 | Olympique Lyonnais |
Biggest Lyon Victory vs Istres
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Biggest Istres Defeat vs Lyon
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Last 5 Istres Home Matches
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| 2024 24 August | | CFA | Istres | 2 - 1 | Marignane Gignac CB |
| 2024 18 May | | CFA 2 | Istres | 3 - 3 | Rousset-Ste Victoire |
| 2024 28 April | | CFA 2 | Istres | 1 - 1 | Ardziv |
| 2024 13 April | | CFA 2 | Istres | 0 - 2 | Cagnes-Le Cros |
| 2024 23 March | | CFA 2 | Istres | 0 - 1 | Agde |
Last 5 Lyon Home Matches
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| 2024 30 August | | Ligue 1 | Olympique Lyonnais | 4 - 3 | Strasbourg |
| 2024 24 August | | Ligue 1 | Olympique Lyonnais | 0 - 2 | Monaco |
| 2024 25 May | | Cup | Olympique Lyonnais | 1 - 2 | Paris St Germain |
| 2024 19 May | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Strasbourg |
| 2024 28 April | | Ligue 1 | Olympique Lyonnais | 3 - 2 | Monaco |
Last 5 Istres Away Matches
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| 2024 30 August | | CFA | Saint-Priest | 1 - 0 | Istres |
| 2024 16 August | | CFA | Jura Sud Foot | 2 - 0 | Istres |
| 2024 11 May | | CFA 2 | Olympique Marseille II | 1 - 1 | Istres |
| 2024 21 April | | CFA 2 | St Clement Montferrier | 0 - 2 | Istres |
| 2024 6 April | | CFA 2 | Corte | 1 - 1 | Istres |
Last 5 Lyon Away Matches
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| 2024 18 August | | Ligue 1 | Stade Rennes | 3 - 0 | Olympique Lyonnais |
| 2024 12 May | | Ligue 1 | Clermont | 0 - 1 | Olympique Lyonnais |
| 2024 6 May | | Ligue 1 | Lille | 3 - 4 | Olympique Lyonnais |
| 2024 21 April | | Ligue 1 | Paris St Germain | 4 - 1 | Olympique Lyonnais |
| 2024 7 April | | Ligue 1 | Nantes | 1 - 3 | Olympique Lyonnais |