This page lists the head-to-head record of Lyon vs Istres including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Istres | Lyon | Draws |
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| Total Matches | 2 | 0 | 1 | 1 |
| At Stade Parsemain | 1 | 0 | 1 | 0 |
| At Parc OL | 1 | 0 | 0 | 1 |
| Ligue 1 Matches | 2 | 0 | 1 | 1 |
| Total Goals Scored | 3 | 1 | 2 | |
Last 50 Istres vs Lyon Matches
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
| 2004 22 October | | Ligue 1 | Istres | 0 - 0 | Olympique Lyonnais |
Biggest Lyon Victory vs Istres
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Biggest Istres Defeat vs Lyon
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| 2005 11 March | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Istres |
Last 5 Istres Home Matches
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| 2026 17 January | | CFA | Istres | 2 - 0 | Nimes |
| 2026 10 January | | Cup | Istres | 0 - 2 | Laval |
| 2025 13 December | | CFA | Istres | 0 - 0 | Grasse |
| 2025 22 November | | CFA | Istres | 4 - 0 | Toulon |
| 2025 31 October | | CFA | Istres | 0 - 1 | Rumilly Vallieres |
Last 5 Lyon Home Matches
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| 2026 1 February | | Ligue 1 | Olympique Lyonnais | 1 - 0 | Lille |
| 2026 29 January | | UEFA Europa League | Olympique Lyonnais | 4 - 2 | PAOK |
| 2026 18 January | | Ligue 1 | Olympique Lyonnais | 2 - 1 | Brest |
| 2025 21 December | | Cup | Olympique Lyonnais | 3 - 0 | Saint-Cyr Collonges |
| 2025 14 December | | Ligue 1 | Olympique Lyonnais | 1 - 0 | Le Havre |
Last 5 Istres Away Matches
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| 2026 30 January | | CFA | Creteil | 1 - 2 | Istres |
| 2026 24 January | | CFA | Rousset-Ste Victoire | 0 - 1 | Istres |
| 2025 20 December | | Cup | SA Merignac | 0 - 0 | Istres |
| 2025 5 December | | CFA | Bobigny | 1 - 1 | Istres |
| 2025 29 November | | Cup | Seyssinet-Pariset | 0 - 2 | Istres |
Last 5 Lyon Away Matches
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| 2026 25 January | | Ligue 1 | Metz | 2 - 5 | Olympique Lyonnais |
| 2026 22 January | | UEFA Europa League | Young Boys | 0 - 1 | Olympique Lyonnais |
| 2026 11 January | | Cup | Lille | 1 - 2 | Olympique Lyonnais |
| 2026 3 January | | Ligue 1 | Monaco | 1 - 3 | Olympique Lyonnais |
| 2025 7 December | | Ligue 1 | Lorient | 1 - 0 | Olympique Lyonnais |