This page lists the head-to-head record of Karlsruhe SC vs Hoffenheim including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Hoffenheim | Karlsruhe SC | Draws |
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| Total Matches | 2 | 1 | 0 | 1 |
| At Rhein-Neckar-Arena | 1 | 0 | 0 | 1 |
| At Wildparkstadion | 1 | 1 | 0 | 0 |
| Bundesliga Matches | 2 | 1 | 0 | 1 |
| Total Goals Scored | 9 | 6 | 3 | |
Last 50 Hoffenheim vs Karlsruhe SC Matches
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| 2009 18 April | | Bundesliga | Karlsruher SC | 2 - 2 | Hoffenheim |
| 2008 1 November | | Bundesliga | Hoffenheim | 4 - 1 | Karlsruher SC |
Biggest Hoffenheim Victory vs Karlsruhe SC
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| 2008 1 November | | Bundesliga | Hoffenheim | 4 - 1 | Karlsruher SC |
Biggest Karlsruhe SC Defeat vs Hoffenheim
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| 2008 1 November | | Bundesliga | Hoffenheim | 4 - 1 | Karlsruher SC |
Last 5 Hoffenheim Home Matches
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| 2025 13 December | | Bundesliga | Hoffenheim | 4 - 1 | Hamburger SV |
| 2025 29 November | | Bundesliga | Hoffenheim | 3 - 0 | Augsburg |
| 2025 8 November | | Bundesliga | Hoffenheim | 3 - 1 | RB Leipzig |
| 2025 25 October | | Bundesliga | Hoffenheim | 3 - 1 | Heidenheim |
| 2025 3 October | | Bundesliga | Hoffenheim | 0 - 1 | FC Koln |
Last 5 Karlsruhe SC Home Matches
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| 2025 13 December | | Bundesliga 2 | Karlsruher SC | 0 - 4 | Paderborn |
| 2025 23 November | | Bundesliga 2 | Karlsruher SC | 2 - 3 | Elversberg |
| 2025 1 November | | Bundesliga 2 | Karlsruher SC | 2 - 1 | Schalke 04 |
| 2025 18 October | | Bundesliga 2 | Karlsruher SC | 2 - 3 | Kaiserslautern |
| 2025 27 September | | Bundesliga 2 | Karlsruher SC | 1 - 0 | Magdeburg |
Last 5 Hoffenheim Away Matches
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| 2025 20 December | | Bundesliga | Stuttgart | 0 - 0 | Hoffenheim |
| 2025 7 December | | Bundesliga | Borussia Dortmund | 2 - 0 | Hoffenheim |
| 2025 21 November | | Bundesliga | Mainz 05 | 1 - 1 | Hoffenheim |
| 2025 2 November | | Bundesliga | Wolfsburg | 2 - 3 | Hoffenheim |
| 2025 28 October | | Cup | St. Pauli | 1 - 1 | Hoffenheim |
Last 5 Karlsruhe SC Away Matches
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| 2025 20 December | | Bundesliga 2 | Bochum | 2 - 2 | Karlsruher SC |
| 2025 6 December | | Bundesliga 2 | Darmstadt 98 | 3 - 2 | Karlsruher SC |
| 2025 28 November | | Bundesliga 2 | Hannover 96 | 3 - 0 | Karlsruher SC |
| 2025 8 November | | Bundesliga 2 | Arminia Bielefeld | 4 - 0 | Karlsruher SC |
| 2025 28 October | | Cup | Borussia M'gladbach | 3 - 1 | Karlsruher SC |