This page lists the head-to-head record of FSV Mainz vs Hoffenheim including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Hoffenheim | FSV Mainz | Draws |
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| Total Matches | 35 | 10 | 15 | 10 |
| At Rhein-Neckar-Arena | 18 | 3 | 9 | 6 |
| At Opel Arena | 17 | 7 | 6 | 4 |
| Bundesliga 2 Matches | 2 | 1 | 0 | 1 |
| Bundesliga Matches | 33 | 9 | 15 | 9 |
| Total Goals Scored | 112 | 52 | 60 | |
Last 50 Hoffenheim vs FSV Mainz Matches
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| 2025 21 November | | Bundesliga | Mainz 05 | 1 - 1 | Hoffenheim |
| 2025 12 April | | Bundesliga | Hoffenheim | 2 - 0 | Mainz 05 |
| 2024 1 December | | Bundesliga | Mainz 05 | 2 - 0 | Hoffenheim |
| 2024 13 April | | Bundesliga | Mainz 05 | 4 - 1 | Hoffenheim |
| 2023 26 November | | Bundesliga | Hoffenheim | 1 - 1 | Mainz 05 |
| 2023 4 March | | Bundesliga | Mainz 05 | 1 - 0 | Hoffenheim |
| 2022 10 September | | Bundesliga | Hoffenheim | 4 - 1 | Mainz 05 |
| 2022 5 February | | Bundesliga | Mainz 05 | 2 - 0 | Hoffenheim |
| 2021 11 September | | Bundesliga | Hoffenheim | 0 - 2 | Mainz 05 |
| 2021 21 March | | Bundesliga | Hoffenheim | 1 - 2 | Mainz 05 |
| 2020 29 November | | Bundesliga | Mainz 05 | 1 - 1 | Hoffenheim |
| 2020 30 May | | Bundesliga | Mainz 05 | 0 - 1 | Hoffenheim |
| 2019 24 November | | Bundesliga | Hoffenheim | 1 - 5 | Mainz 05 |
| 2019 18 May | | Bundesliga | Mainz 05 | 4 - 2 | Hoffenheim |
| 2018 23 December | | Bundesliga | Hoffenheim | 1 - 1 | Mainz 05 |
| 2018 10 February | | Bundesliga | Hoffenheim | 4 - 2 | Mainz 05 |
| 2017 20 September | | Bundesliga | Mainz 05 | 2 - 3 | Hoffenheim |
| 2017 4 February | | Bundesliga | Hoffenheim | 4 - 0 | Mainz 05 |
| 2016 11 September | | Bundesliga | Mainz 05 | 4 - 4 | Hoffenheim |
| 2016 20 February | | Bundesliga | Hoffenheim | 3 - 2 | Mainz 05 |
| 2015 18 September | | Bundesliga | Mainz 05 | 3 - 1 | Hoffenheim |
| 2015 28 February | | Bundesliga | Hoffenheim | 2 - 0 | Mainz 05 |
| 2014 26 September | | Bundesliga | Mainz 05 | 0 - 0 | Hoffenheim |
| 2014 15 March | | Bundesliga | Hoffenheim | 2 - 4 | Mainz 05 |
| 2013 5 October | | Bundesliga | Mainz 05 | 2 - 2 | Hoffenheim |
| 2013 16 March | | Bundesliga | Hoffenheim | 0 - 0 | Mainz 05 |
| 2012 27 October | | Bundesliga | Mainz 05 | 3 - 0 | Hoffenheim |
| 2012 17 February | | Bundesliga | Hoffenheim | 1 - 1 | Mainz 05 |
| 2011 10 September | | Bundesliga | Mainz 05 | 0 - 4 | Hoffenheim |
| 2011 26 February | | Bundesliga | Hoffenheim | 1 - 2 | Mainz 05 |
| 2010 2 October | | Bundesliga | Mainz 05 | 4 - 2 | Hoffenheim |
| 2010 7 March | | Bundesliga | Hoffenheim | 0 - 1 | Mainz 05 |
| 2009 3 October | | Bundesliga | Mainz 05 | 2 - 1 | Hoffenheim |
| 2008 23 March | | Bundesliga 2 | Mainz 05 | 1 - 1 | Hoffenheim |
| 2007 30 September | | Bundesliga 2 | Hoffenheim | 1 - 0 | Mainz 05 |
Biggest Hoffenheim Victory vs FSV Mainz
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| 2017 4 February | | Bundesliga | Hoffenheim | 4 - 0 | Mainz 05 |
Biggest FSV Mainz Victory vs Hoffenheim
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| 2019 24 November | | Bundesliga | Hoffenheim | 1 - 5 | Mainz 05 |
Biggest Hoffenheim Defeat vs FSV Mainz
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| 2019 24 November | | Bundesliga | Hoffenheim | 1 - 5 | Mainz 05 |
Biggest FSV Mainz Defeat vs Hoffenheim
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| 2017 4 February | | Bundesliga | Hoffenheim | 4 - 0 | Mainz 05 |
Last 5 Hoffenheim Home Matches
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| 2025 8 November | | Bundesliga | Hoffenheim | 3 - 1 | RB Leipzig |
| 2025 25 October | | Bundesliga | Hoffenheim | 3 - 1 | Heidenheim |
| 2025 3 October | | Bundesliga | Hoffenheim | 0 - 1 | FC Koln |
| 2025 20 September | | Bundesliga | Hoffenheim | 1 - 4 | Bayern Munchen |
| 2025 30 August | | Bundesliga | Hoffenheim | 1 - 3 | Eintracht Frankfurt |
Last 5 FSV Mainz Home Matches
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| 2025 21 November | | Bundesliga | Mainz 05 | 1 - 1 | Hoffenheim |
| 2025 6 November | | Europa Conference League | Mainz 05 | 2 - 1 | Fiorentina |
| 2025 1 November | | Bundesliga | Mainz 05 | 1 - 1 | Werder Bremen |
| 2025 29 October | | Cup | Mainz 05 | 0 - 2 | Stuttgart |
| 2025 23 October | | Europa Conference League | Mainz 05 | 1 - 0 | Zrinjski |
Last 5 Hoffenheim Away Matches
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| 2025 21 November | | Bundesliga | Mainz 05 | 1 - 1 | Hoffenheim |
| 2025 2 November | | Bundesliga | Wolfsburg | 2 - 3 | Hoffenheim |
| 2025 28 October | | Cup | St. Pauli | 1 - 1 | Hoffenheim |
| 2025 19 October | | Bundesliga | St. Pauli | 0 - 3 | Hoffenheim |
| 2025 28 September | | Bundesliga | Freiburg | 1 - 1 | Hoffenheim |
Last 5 FSV Mainz Away Matches
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| 2025 9 November | | Bundesliga | Eintracht Frankfurt | 1 - 0 | Mainz 05 |
| 2025 26 October | | Bundesliga | Stuttgart | 2 - 1 | Mainz 05 |
| 2025 5 October | | Bundesliga | Hamburger SV | 4 - 0 | Mainz 05 |
| 2025 2 October | | Europa Conference League | Omonia Nicosia | 0 - 1 | Mainz 05 |
| 2025 20 September | | Bundesliga | Augsburg | 1 - 4 | Mainz 05 |