This page lists the head-to-head record of Anderlecht vs FC Brussels including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | FC Brussels | Anderlecht | Draws |
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| Total Matches | 8 | 0 | 7 | 1 |
| At Stade Edmond Machtens | 4 | 0 | 4 | 0 |
| At Constant Vanden Stock Stadion | 4 | 0 | 3 | 1 |
| Pro League Matches | 8 | 0 | 7 | 1 |
| Total Goals Scored | 24 | 3 | 21 | |
Last 50 FC Brussels vs Anderlecht Matches
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| 2008 9 February | | Pro League | RWDM Brussels | 2 - 4 | Anderlecht |
| 2007 25 August | | Pro League | Anderlecht | 3 - 0 | RWDM Brussels |
| 2007 12 May | | Pro League | Anderlecht | 6 - 0 | RWDM Brussels |
| 2006 9 December | | Pro League | RWDM Brussels | 0 - 1 | Anderlecht |
| 2006 16 February | | Pro League | Anderlecht | 2 - 0 | RWDM Brussels |
| 2005 16 September | | Pro League | RWDM Brussels | 1 - 1 | Anderlecht |
| 2005 18 March | | Pro League | Anderlecht | 3 - 0 | RWDM Brussels |
| 2004 14 October | | Pro League | RWDM Brussels | 0 - 1 | Anderlecht |
Biggest Anderlecht Victory vs FC Brussels
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| 2007 12 May | | Pro League | Anderlecht | 6 - 0 | RWDM Brussels |
Biggest FC Brussels Defeat vs Anderlecht
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| 2007 12 May | | Pro League | Anderlecht | 6 - 0 | RWDM Brussels |
Last 5 FC Brussels Home Matches
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| 2025 24 September | | Second Division | RWDM Brussels | 1 - 2 | Kortrijk |
| 2025 14 September | | Second Division | RWDM Brussels | 5 - 0 | Seraing United |
| 2025 23 August | | Second Division | RWDM Brussels | 0 - 2 | Waasland-Beveren |
| 2025 9 August | | Second Division | RWDM Brussels | 3 - 3 | Lommel United |
| 2014 26 April | | Second Division | RWDM Brussels | 1 - 3 | Tubize |
Last 5 Anderlecht Home Matches
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| 2025 5 October | | Pro League | Anderlecht | 1 - 0 | Standard Liege |
| 2025 23 September | | Pro League | Anderlecht | 1 - 0 | Gent |
| 2025 20 September | | Pro League | Anderlecht | 0 - 0 | Antwerp |
| 2025 14 September | | Pro League | Anderlecht | 1 - 1 | Genk |
| 2025 21 August | | Europa Conference League | Anderlecht | 1 - 1 | AEK Athens |
Last 5 FC Brussels Away Matches
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| 2025 4 October | | Second Division | AS Eupen | 2 - 2 | RWDM Brussels |
| 2025 28 September | | Second Division | KAA Gent II | 0 - 2 | RWDM Brussels |
| 2025 19 September | | Second Division | Lierse Kempenzonen | 2 - 0 | RWDM Brussels |
| 2025 6 September | | Cup | Dessel Sport | 2 - 4 | RWDM Brussels |
| 2025 16 August | | Second Division | Lokeren-Temse | 1 - 3 | RWDM Brussels |
Last 5 Anderlecht Away Matches
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| 2025 26 September | | Pro League | OH Leuven | 1 - 1 | Anderlecht |
| 2025 31 August | | Pro League | Union Saint-Gilloise | 2 - 0 | Anderlecht |
| 2025 28 August | | Europa Conference League | AEK Athens | 2 - 0 | Anderlecht |
| 2025 17 August | | Pro League | Dender | 0 - 2 | Anderlecht |
| 2025 14 August | | Europa Conference League | Sheriff | 1 - 1 | Anderlecht |