This page lists the head-to-head record of Anderlecht vs FC Brussels including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | FC Brussels | Anderlecht | Draws |
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| Total Matches | 8 | 0 | 7 | 1 |
| At Stade Edmond Machtens | 4 | 0 | 4 | 0 |
| At Constant Vanden Stock Stadion | 4 | 0 | 3 | 1 |
| Pro League Matches | 8 | 0 | 7 | 1 |
| Total Goals Scored | 24 | 3 | 21 | |
Last 50 FC Brussels vs Anderlecht Matches
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| 2008 9 February | | Pro League | RWDM Brussels | 2 - 4 | Anderlecht |
| 2007 25 August | | Pro League | Anderlecht | 3 - 0 | RWDM Brussels |
| 2007 12 May | | Pro League | Anderlecht | 6 - 0 | RWDM Brussels |
| 2006 9 December | | Pro League | RWDM Brussels | 0 - 1 | Anderlecht |
| 2006 16 February | | Pro League | Anderlecht | 2 - 0 | RWDM Brussels |
| 2005 16 September | | Pro League | RWDM Brussels | 1 - 1 | Anderlecht |
| 2005 18 March | | Pro League | Anderlecht | 3 - 0 | RWDM Brussels |
| 2004 14 October | | Pro League | RWDM Brussels | 0 - 1 | Anderlecht |
Biggest Anderlecht Victory vs FC Brussels
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| 2007 12 May | | Pro League | Anderlecht | 6 - 0 | RWDM Brussels |
Biggest FC Brussels Defeat vs Anderlecht
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| 2007 12 May | | Pro League | Anderlecht | 6 - 0 | RWDM Brussels |
Last 5 FC Brussels Home Matches
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| 2014 26 April | | Second Division | RWDM Brussels | 1 - 3 | Tubize |
| 2014 12 April | | Second Division | RWDM Brussels | 1 - 2 | Royal Excel Mouscron |
| 2014 29 March | | Second Division | RWDM Brussels | 5 - 0 | Heist |
| 2014 9 March | | Second Division | RWDM Brussels | 1 - 1 | Antwerp |
| 2014 16 February | | Second Division | RWDM Brussels | 0 - 0 | White Star Bruxelles |
Last 5 Anderlecht Home Matches
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| 2024 8 December | | Pro League | Anderlecht | 2 - 1 | Beerschot-Wilrijk |
| 2024 5 December | | Cup | Anderlecht | 4 - 1 | Westerlo |
| 2024 28 November | | UEFA Europa League | Anderlecht | 2 - 2 | Porto |
| 2024 24 November | | Pro League | Anderlecht | 6 - 0 | Gent |
| 2024 3 November | | Pro League | Anderlecht | 4 - 0 | Kortrijk |
Last 5 FC Brussels Away Matches
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| 2014 20 April | | Second Division | AS Eupen | 1 - 0 | RWDM Brussels |
| 2014 5 April | | Second Division | Geel-Meerhout | 2 - 0 | RWDM Brussels |
| 2014 16 March | | Second Division | Eendracht Aalst | 2 - 1 | RWDM Brussels |
| 2014 1 March | | Second Division | Dessel Sport | 0 - 1 | RWDM Brussels |
| 2014 8 February | | Second Division | KSV Roeselare | 0 - 1 | RWDM Brussels |
Last 5 Anderlecht Away Matches
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| 2024 15 December | | Pro League | Sint-Truiden | 0 - 2 | Anderlecht |
| 2024 12 December | | UEFA Europa League | Slavia Praha | 1 - 2 | Anderlecht |
| 2024 1 December | | Pro League | OH Leuven | 0 - 0 | Anderlecht |
| 2024 10 November | | Pro League | Cercle Brugge | 0 - 5 | Anderlecht |
| 2024 7 November | | UEFA Europa League | Rigas FS | 1 - 1 | Anderlecht |