This page lists the head-to-head record of Perugia vs Empoli including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Empoli | Perugia | Draws |
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| Total Matches | 12 | 9 | 1 | 2 |
| At Stadio Carlo Castellani | 6 | 4 | 1 | 1 |
| At | 6 | 5 | 0 | 1 |
| Serie B Matches | 6 | 6 | 0 | 0 |
| Serie A Matches | 6 | 3 | 1 | 2 |
| Total Goals Scored | 31 | 22 | 9 | |
Last 50 Empoli vs Perugia Matches
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| 2020 24 February | | Serie B | Perugia | 0 - 1 | Empoli |
| 2019 28 September | | Serie B | Empoli | 3 - 0 | Perugia |
| 2018 18 May | | Serie B | Empoli | 2 - 1 | Perugia |
| 2017 28 December | | Serie B | Perugia | 2 - 4 | Empoli |
| 2005 25 March | | Serie B | Empoli | 1 - 0 | Perugia |
| 2004 25 October | | Serie B | Perugia | 0 - 2 | Empoli |
| 2004 3 April | | Serie A | Empoli | 1 - 0 | Perugia |
| 2003 29 November | | Serie A | Perugia | 1 - 1 | Empoli |
| 2003 15 February | | Serie A | Empoli | 1 - 1 | Perugia |
| 2002 28 September | | Serie A | Perugia | 1 - 3 | Empoli |
| 1999 6 March | | Serie A | Perugia | 3 - 1 | Empoli |
| 1998 31 October | | Serie A | Empoli | 2 - 0 | Perugia |
Biggest Empoli Victory vs Perugia
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| 2019 28 September | | Serie B | Empoli | 3 - 0 | Perugia |
Biggest Perugia Victory vs Empoli
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| 1999 6 March | | Serie A | Perugia | 3 - 1 | Empoli |
Biggest Empoli Defeat vs Perugia
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| 1999 6 March | | Serie A | Perugia | 3 - 1 | Empoli |
Biggest Perugia Defeat vs Empoli
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| 2019 28 September | | Serie B | Empoli | 3 - 0 | Perugia |
Last 5 Empoli Home Matches
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| 2025 1 October | | Serie B | Empoli | 1 - 1 | Monza |
| 2025 28 September | | Serie B | Empoli | 2 - 2 | Carrarese |
| 2025 14 September | | Serie B | Empoli | 1 - 1 | Spezia |
| 2025 23 August | | Serie B | Empoli | 3 - 1 | Calcio Padova |
| 2025 15 August | | Cup | Empoli | 1 - 1 | Reggiana |
Last 5 Perugia Home Matches
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| 2025 27 September | | Serie C1 - A | Perugia | 0 - 1 | Pianese |
| 2025 23 September | | Serie C1 - A | Perugia | 1 - 2 | Sambenedettese |
| 2025 14 September | | Serie C1 - A | Perugia | 0 - 2 | Ascoli Picchio |
| 2025 22 August | | Serie C1 - A | Perugia | 0 - 0 | Nuova Monterosi |
| 2025 27 April | | Serie C1 - A | Perugia | 3 - 0 | Pontedera |
Last 5 Empoli Away Matches
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| 2025 5 October | | Serie B | Sudtirol | 1 - 2 | Empoli |
| 2025 25 September | | Cup | Genoa | 3 - 1 | Empoli |
| 2025 21 September | | Serie B | Pescara | 4 - 0 | Empoli |
| 2025 29 August | | Serie B | Reggiana | 3 - 1 | Empoli |
| 2025 18 May | | Serie A | Monza | 1 - 3 | Empoli |
Last 5 Perugia Away Matches
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| 2025 5 October | | Serie C1 - A | Athletic Carpi | 2 - 0 | Perugia |
| 2025 19 September | | Serie C1 - A | Ravenna | 3 - 2 | Perugia |
| 2025 6 September | | Serie C1 - A | Gubbio | 1 - 1 | Perugia |
| 2025 30 August | | Serie C1 - A | Bra | 2 - 2 | Perugia |
| 2025 23 April | | Serie C1 - A | Citta di Campobasso | 2 - 1 | Perugia |