This page lists the head-to-head record of Palermo vs Empoli including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Empoli | Palermo | Draws |
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| Total Matches | 18 | 9 | 4 | 5 |
| At Stadio Carlo Castellani | 9 | 3 | 3 | 3 |
| At Stadio Renzo Barbera | 9 | 6 | 1 | 2 |
| Serie B Matches | 6 | 3 | 1 | 2 |
| Serie A Matches | 12 | 6 | 3 | 3 |
| Total Goals Scored | 46 | 29 | 17 | |
Last 50 Empoli vs Palermo Matches
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| 2018 2 February | | Serie B | Empoli | 4 - 0 | Palermo |
| 2017 9 September | | Serie B | Palermo | 3 - 3 | Empoli |
| 2017 28 May | | Serie A | Palermo | 2 - 1 | Empoli |
| 2017 7 January | | Serie A | Empoli | 1 - 0 | Palermo |
| 2016 19 March | | Serie A | Empoli | 0 - 0 | Palermo |
| 2015 2 November | | Serie A | Palermo | 0 - 1 | Empoli |
| 2015 1 March | | Serie A | Palermo | 0 - 0 | Empoli |
| 2014 5 October | | Serie A | Empoli | 3 - 0 | Palermo |
| 2014 3 February | | Serie B | Empoli | 1 - 1 | Palermo |
| 2013 31 August | | Serie B | Palermo | 1 - 2 | Empoli |
| 2008 27 February | | Serie A | Palermo | 2 - 0 | Empoli |
| 2007 30 September | | Serie A | Empoli | 3 - 1 | Palermo |
| 2007 11 February | | Serie A | Palermo | 0 - 1 | Empoli |
| 2006 24 September | | Serie A | Empoli | 2 - 0 | Palermo |
| 2006 11 February | | Serie A | Empoli | 0 - 1 | Palermo |
| 2005 1 October | | Serie A | Palermo | 2 - 2 | Empoli |
| 2002 12 January | | Serie B | Palermo | 1 - 0 | Empoli |
| 2001 25 August | | Serie B | Empoli | 5 - 3 | Palermo |
Biggest Empoli Victory vs Palermo
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| 2018 2 February | | Serie B | Empoli | 4 - 0 | Palermo |
Biggest Palermo Victory vs Empoli
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| 2008 27 February | | Serie A | Palermo | 2 - 0 | Empoli |
Biggest Empoli Defeat vs Palermo
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| 2008 27 February | | Serie A | Palermo | 2 - 0 | Empoli |
Biggest Palermo Defeat vs Empoli
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| 2018 2 February | | Serie B | Empoli | 4 - 0 | Palermo |
Last 5 Empoli Home Matches
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| 2024 4 November | | Serie A | Empoli | 1 - 0 | Como |
| 2024 30 October | | Serie A | Empoli | 0 - 3 | Internazionale |
| 2024 20 October | | Serie A | Empoli | 0 - 1 | Napoli |
| 2024 29 September | | Serie A | Empoli | 0 - 0 | Fiorentina |
| 2024 14 September | | Serie A | Empoli | 0 - 0 | Juventus |
Last 5 Palermo Home Matches
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| 2024 3 November | | Serie B | Palermo | 0 - 1 | Cittadella |
| 2024 26 October | | Serie B | Palermo | 2 - 0 | Reggiana |
| 2024 6 October | | Serie B | Palermo | 0 - 1 | Salernitana |
| 2024 21 September | | Serie B | Palermo | 0 - 0 | Cesena |
| 2024 1 September | | Serie B | Palermo | 1 - 1 | Nuova Cosenza |
Last 5 Empoli Away Matches
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| 2024 8 November | | Serie A | Lecce | 1 - 1 | Empoli |
| 2024 27 October | | Serie A | Parma | 1 - 1 | Empoli |
| 2024 6 October | | Serie A | Lazio | 2 - 1 | Empoli |
| 2024 24 September | | Cup | Torino | 1 - 2 | Empoli |
| 2024 20 September | | Serie A | Cagliari | 0 - 2 | Empoli |
Last 5 Palermo Away Matches
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| 2024 8 November | | Serie B | Frosinone | 1 - 1 | Palermo |
| 2024 30 October | | Serie B | Mantova | 0 - 0 | Palermo |
| 2024 19 October | | Serie B | Modena | 2 - 2 | Palermo |
| 2024 30 September | | Serie B | Sudtirol | 1 - 3 | Palermo |
| 2024 26 September | | Cup | Napoli | 5 - 0 | Palermo |