This page lists the head-to-head record of Palermo vs Empoli including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Empoli | Palermo | Draws |
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| Total Matches | 18 | 9 | 4 | 5 |
| At Stadio Carlo Castellani | 9 | 3 | 3 | 3 |
| At Stadio Renzo Barbera | 9 | 6 | 1 | 2 |
| Serie B Matches | 6 | 3 | 1 | 2 |
| Serie A Matches | 12 | 6 | 3 | 3 |
| Total Goals Scored | 46 | 29 | 17 | |
Last 50 Empoli vs Palermo Matches
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| 2018 2 February | | Serie B | Empoli | 4 - 0 | Palermo |
| 2017 9 September | | Serie B | Palermo | 3 - 3 | Empoli |
| 2017 28 May | | Serie A | Palermo | 2 - 1 | Empoli |
| 2017 7 January | | Serie A | Empoli | 1 - 0 | Palermo |
| 2016 19 March | | Serie A | Empoli | 0 - 0 | Palermo |
| 2015 2 November | | Serie A | Palermo | 0 - 1 | Empoli |
| 2015 1 March | | Serie A | Palermo | 0 - 0 | Empoli |
| 2014 5 October | | Serie A | Empoli | 3 - 0 | Palermo |
| 2014 3 February | | Serie B | Empoli | 1 - 1 | Palermo |
| 2013 31 August | | Serie B | Palermo | 1 - 2 | Empoli |
| 2008 27 February | | Serie A | Palermo | 2 - 0 | Empoli |
| 2007 30 September | | Serie A | Empoli | 3 - 1 | Palermo |
| 2007 11 February | | Serie A | Palermo | 0 - 1 | Empoli |
| 2006 24 September | | Serie A | Empoli | 2 - 0 | Palermo |
| 2006 11 February | | Serie A | Empoli | 0 - 1 | Palermo |
| 2005 1 October | | Serie A | Palermo | 2 - 2 | Empoli |
| 2002 12 January | | Serie B | Palermo | 1 - 0 | Empoli |
| 2001 25 August | | Serie B | Empoli | 5 - 3 | Palermo |
Biggest Empoli Victory vs Palermo
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| 2018 2 February | | Serie B | Empoli | 4 - 0 | Palermo |
Biggest Palermo Victory vs Empoli
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| 2008 27 February | | Serie A | Palermo | 2 - 0 | Empoli |
Biggest Empoli Defeat vs Palermo
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| 2008 27 February | | Serie A | Palermo | 2 - 0 | Empoli |
Biggest Palermo Defeat vs Empoli
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| 2018 2 February | | Serie B | Empoli | 4 - 0 | Palermo |
Last 5 Empoli Home Matches
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| 2025 25 January | | Serie A | Empoli | 1 - 1 | Bologna |
| 2025 11 January | | Serie A | Empoli | 1 - 3 | Lecce |
| 2024 28 December | | Serie A | Empoli | 1 - 2 | Genoa |
| 2024 13 December | | Serie A | Empoli | 0 - 1 | Torino |
| 2024 25 November | | Serie A | Empoli | 1 - 1 | Udinese |
Last 5 Palermo Home Matches
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| 2025 19 January | | Serie B | Palermo | 1 - 0 | Juve Stabia |
| 2025 12 January | | Serie B | Palermo | 2 - 0 | Modena |
| 2024 26 December | | Serie B | Palermo | 1 - 0 | Bari 1908 |
| 2024 15 December | | Serie B | Palermo | 1 - 2 | Catanzaro |
| 2024 1 December | | Serie B | Palermo | 2 - 0 | Spezia |
Last 5 Empoli Away Matches
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| 2025 19 January | | Serie A | Internazionale | 3 - 1 | Empoli |
| 2025 4 January | | Serie A | Venezia | 1 - 1 | Empoli |
| 2024 22 December | | Serie A | Atalanta | 3 - 2 | Empoli |
| 2024 8 December | | Serie A | Hellas Verona | 1 - 4 | Empoli |
| 2024 4 December | | Cup | Fiorentina | 2 - 2 | Empoli |
Last 5 Palermo Away Matches
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| 2025 26 January | | Serie B | Reggiana | 2 - 1 | Palermo |
| 2024 29 December | | Serie B | Cittadella | 2 - 1 | Palermo |
| 2024 21 December | | Serie B | Sassuolo | 2 - 1 | Palermo |
| 2024 7 December | | Serie B | Carrarese | 1 - 0 | Palermo |
| 2024 8 November | | Serie B | Frosinone | 1 - 1 | Palermo |