This page lists the head-to-head record of FSV Mainz vs Bayer Leverkusen including biggest victories and defeats between the two sides, and H2H stats in all competitions.
Overall H2H Record - Summary
| Total | Bayer Leverkusen | FSV Mainz | Draws |
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| Total Matches | 36 | 18 | 12 | 6 |
| At BayArena | 18 | 10 | 7 | 1 |
| At Opel Arena | 18 | 8 | 5 | 5 |
| Cup Matches | 1 | 0 | 0 | 1 |
| Bundesliga Matches | 35 | 18 | 12 | 5 |
| Total Goals Scored | 103 | 58 | 45 | |
Last 50 Bayer Leverkusen vs FSV Mainz Matches
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| 2023 30 September | | Bundesliga | Mainz 05 | 0 - 3 | Bayer Leverkusen |
| 2023 19 February | | Bundesliga | Bayer Leverkusen | 2 - 3 | Mainz 05 |
| 2022 27 August | | Bundesliga | Mainz 05 | 0 - 3 | Bayer Leverkusen |
| 2022 18 February | | Bundesliga | Mainz 05 | 3 - 2 | Bayer Leverkusen |
| 2021 25 September | | Bundesliga | Bayer Leverkusen | 1 - 0 | Mainz 05 |
| 2021 13 February | | Bundesliga | Bayer Leverkusen | 2 - 2 | Mainz 05 |
| 2020 17 October | | Bundesliga | Mainz 05 | 0 - 1 | Bayer Leverkusen |
| 2020 27 June | | Bundesliga | Bayer Leverkusen | 1 - 0 | Mainz 05 |
| 2019 21 December | | Bundesliga | Mainz 05 | 0 - 1 | Bayer Leverkusen |
| 2019 8 February | | Bundesliga | Mainz 05 | 1 - 5 | Bayer Leverkusen |
| 2018 23 September | | Bundesliga | Bayer Leverkusen | 1 - 0 | Mainz 05 |
| 2018 28 January | | Bundesliga | Bayer Leverkusen | 2 - 0 | Mainz 05 |
| 2017 9 September | | Bundesliga | Mainz 05 | 3 - 1 | Bayer Leverkusen |
| 2017 25 February | | Bundesliga | Bayer Leverkusen | 0 - 2 | Mainz 05 |
| 2016 24 September | | Bundesliga | Mainz 05 | 2 - 3 | Bayer Leverkusen |
| 2016 28 February | | Bundesliga | Mainz 05 | 3 - 1 | Bayer Leverkusen |
| 2015 23 September | | Bundesliga | Bayer Leverkusen | 1 - 0 | Mainz 05 |
| 2015 11 April | | Bundesliga | Mainz 05 | 2 - 3 | Bayer Leverkusen |
| 2014 8 November | | Bundesliga | Bayer Leverkusen | 0 - 0 | Mainz 05 |
| 2014 1 March | | Bundesliga | Bayer Leverkusen | 0 - 1 | Mainz 05 |
| 2013 21 September | | Bundesliga | Mainz 05 | 1 - 4 | Bayer Leverkusen |
| 2013 9 March | | Bundesliga | Mainz 05 | 1 - 0 | Bayer Leverkusen |
| 2012 20 October | | Bundesliga | Bayer Leverkusen | 2 - 2 | Mainz 05 |
| 2012 22 January | | Bundesliga | Bayer Leverkusen | 3 - 2 | Mainz 05 |
| 2011 7 August | | Bundesliga | Mainz 05 | 2 - 0 | Bayer Leverkusen |
| 2011 13 March | | Bundesliga | Mainz 05 | 0 - 1 | Bayer Leverkusen |
| 2010 24 October | | Bundesliga | Bayer Leverkusen | 0 - 1 | Mainz 05 |
| 2010 16 January | | Bundesliga | Bayer Leverkusen | 4 - 2 | Mainz 05 |
| 2009 8 August | | Bundesliga | Mainz 05 | 2 - 2 | Bayer Leverkusen |
| 2009 21 April | | Cup | Bayer Leverkusen | 1 - 1 | Mainz 05 |
| 2007 31 March | | Bundesliga | Mainz 05 | 1 - 3 | Bayer Leverkusen |
| 2006 4 November | | Bundesliga | Bayer Leverkusen | 1 - 1 | Mainz 05 |
| 2006 17 March | | Bundesliga | Bayer Leverkusen | 1 - 2 | Mainz 05 |
| 2005 14 October | | Bundesliga | Mainz 05 | 3 - 1 | Bayer Leverkusen |
| 2005 12 February | | Bundesliga | Bayer Leverkusen | 2 - 0 | Mainz 05 |
| 2004 10 September | | Bundesliga | Mainz 05 | 2 - 0 | Bayer Leverkusen |
Biggest Bayer Leverkusen Victory vs FSV Mainz
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| 2019 8 February | | Bundesliga | Mainz 05 | 1 - 5 | Bayer Leverkusen |
Biggest FSV Mainz Victory vs Bayer Leverkusen
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| 2011 7 August | | Bundesliga | Mainz 05 | 2 - 0 | Bayer Leverkusen |
Biggest Bayer Leverkusen Defeat vs FSV Mainz
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| 2011 7 August | | Bundesliga | Mainz 05 | 2 - 0 | Bayer Leverkusen |
Biggest FSV Mainz Defeat vs Bayer Leverkusen
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| 2019 8 February | | Bundesliga | Mainz 05 | 1 - 5 | Bayer Leverkusen |
Last 5 Bayer Leverkusen Home Matches
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| 2023 24 September | | Bundesliga | Bayer Leverkusen | 4 - 1 | Heidenheim |
| 2023 21 September | | UEFA Europa League | Bayer Leverkusen | 4 - 0 | Hacken |
| 2023 2 September | | Bundesliga | Bayer Leverkusen | 5 - 1 | Darmstadt 98 |
| 2023 19 August | | Bundesliga | Bayer Leverkusen | 3 - 2 | RB Leipzig |
| 2023 21 May | | Bundesliga | Bayer Leverkusen | 2 - 2 | Borussia M'gladbach |
Last 5 FSV Mainz Home Matches
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| 2023 30 September | | Bundesliga | Mainz 05 | 0 - 3 | Bayer Leverkusen |
| 2023 16 September | | Bundesliga | Mainz 05 | 1 - 3 | Stuttgart |
| 2023 27 August | | Bundesliga | Mainz 05 | 1 - 1 | Eintracht Frankfurt |
| 2023 21 May | | Bundesliga | Mainz 05 | 1 - 4 | Stuttgart |
| 2023 5 May | | Bundesliga | Mainz 05 | 2 - 3 | Schalke 04 |
Last 5 Bayer Leverkusen Away Matches
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| 2023 30 September | | Bundesliga | Mainz 05 | 0 - 3 | Bayer Leverkusen |
| 2023 15 September | | Bundesliga | Bayern Munchen | 2 - 2 | Bayer Leverkusen |
| 2023 26 August | | Bundesliga | Borussia M'gladbach | 0 - 3 | Bayer Leverkusen |
| 2023 12 August | | Cup | Teutonia Ottensen | 0 - 8 | Bayer Leverkusen |
| 2023 27 May | | Bundesliga | Bochum | 3 - 0 | Bayer Leverkusen |
Last 5 FSV Mainz Away Matches
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| 2023 23 September | | Bundesliga | Augsburg | 2 - 1 | Mainz 05 |
| 2023 2 September | | Bundesliga | Werder Bremen | 4 - 0 | Mainz 05 |
| 2023 20 August | | Bundesliga | Union Berlin | 4 - 1 | Mainz 05 |
| 2023 12 August | | Cup | Elversberg | 0 - 1 | Mainz 05 |
| 2023 27 May | | Bundesliga | Borussia Dortmund | 2 - 2 | Mainz 05 |